TY - JOUR
T1 - Do longevity mutants always show trade-offs?
AU - Van Voorhies, Wayne A.
AU - Curtsinger, James W.
AU - Rose, Michael R.
PY - 2006/10
Y1 - 2006/10
N2 - A number of genetic mutations that substantially increase longevity have been discovered in model organisms. Although these long-lived mutants have provided many insights into the factors that affect longevity, the results from such studies should be interpreted with caution. In particular, at least some of these mutations may be poor guides to human medical intervention because they often have deleterious side effects on important biological functions.
AB - A number of genetic mutations that substantially increase longevity have been discovered in model organisms. Although these long-lived mutants have provided many insights into the factors that affect longevity, the results from such studies should be interpreted with caution. In particular, at least some of these mutations may be poor guides to human medical intervention because they often have deleterious side effects on important biological functions.
KW - Aging
KW - Caenorhabditis elegans
KW - Drosophila melanogaster
KW - Mus musculus
UR - http://www.scopus.com/inward/record.url?scp=33751400810&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751400810&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2006.05.006
DO - 10.1016/j.exger.2006.05.006
M3 - Article
C2 - 16790333
AN - SCOPUS:33751400810
SN - 0531-5565
VL - 41
SP - 1055
EP - 1058
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 10
ER -