Does it always help to adjust for misclassification of a binary outcome in logistics regression?

Xianqun Luan, Wei Pan, Susan G Gerberich, Brad Carlin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

It is well known that in logistic regression, where the outcome is measured with error, a biased estimate of the association between the outcome and a risk factor may result if no proper adjustment is made. Hence, it seems tempting to always adjust for possible misclassification of the outcome. Here we show that it is not always beneficial to do so because, though the adjustment reduces the bias, it also inflates the variance, leading to a possibly larger mean squared error of the estimate. In the context of a data set on agricultural injuries, numerical evidence is provided through simulation studies.

Original languageEnglish (US)
Pages (from-to)2221-2234
Number of pages14
JournalStatistics in Medicine
Volume24
Issue number14
DOIs
StatePublished - Jul 30 2005

Keywords

  • Bias
  • Logistic models
  • Mean squared error
  • Measurement error
  • Sensitivity and specificity
  • Simulation

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