Le tranforming growth factor-beta (TGF-beta) a t-il un rôle neuroprotecteur dans l'ischémie cérébrale?

Translated title of the contribution: Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?

Fabian Docagne, Carine Ali, Sylvain Lesne, Olivier Nicole, Eric T. MacKenzie, Alain Buisson, Denis Vivien

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Necrosis and apoptosis are the two fundamental hallmarks of neuronal death in stroke. Nevertheless, thrombolysis, by means of the recombinant serine protease t-PA, remains until now the only approved treatment of stroke in man. Over the last years, the cytokine termed Transforming Growth Factor-beta 1 (TGF-beta 1) has been found to be strongly up regulated in the central nervous system following ischemia-induced brain damage. Recent studies have shown a neuroprotective activity of TGF-beta 1 against ischemia-induced neuronal death. In vitro, TGF-beta 1 protects neurons against excitotoxicity by inhibiting the t-PA-potentiated NMDA-induced neuronal death through a mechanism involving the up-regulation of the type-1 plasminogen activator inhibitor (PAI-1) in astrocytes. Altogether, these observations suggest that either TGF-beta signaling or TGF-beta 1-modulated genes could be good targets for the development of new therapeutic strategies for stroke in man.

Translated title of the contributionDoes transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?
Original languageFrench
Pages (from-to)145-150
Number of pages6
JournalJournal de la Société de biologie
Volume197
Issue number2
DOIs
StatePublished - 2003

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