Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM

Adarsh Sivasankaran; Vladimir Cherkassky; Mark Albrecht; Eric Williams; Martin Maiers

doi:10.1109/ICMLA.2015.166

Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM

Adarsh Sivasankaran, Vladimir Cherkassky, Mark Albrecht, Eric Williams, Martin Maiers

Electrical and Computer Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Donor selection for Hematopoietic Stem Cell Transplant often requires physicians to manually select 3 to 5 donors from a list of 100s of genetically compatible donors as identified by HLA-based matching algorithms. The decision process is complicated by a lack of strict guidelines governing a "secondary" selection process, which is based upon non-HLA donor attributes. Our research is aimed at modeling this "secondary" decision process which can help physicians choose the right donors, based on donor attributes and historical choice behavior. Proposed black box models will help in improving selection consistency.

Original language	English (US)
Title of host publication	Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	831-836
Number of pages	6
ISBN (Electronic)	9781509002870
DOIs	https://doi.org/10.1109/ICMLA.2015.166
State	Published - Mar 2 2016
Event	IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015 - Miami, United States Duration: Dec 9 2015 → Dec 11 2015

Publication series

Name	Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015

Other

Other	IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015
Country/Territory	United States
City	Miami
Period	12/9/15 → 12/11/15

Bibliographical note

Funding Information:
This work was supported, in part, by the Faculty in Industry grant from the University of Minnesota Informatics Institute (UMII), and by ONR grant N00014-14-1-0848

Publisher Copyright:
© 2015 IEEE.

Keywords

Donor selection
Predictive data analytics
SVM classification
Stem cell transplant
Unbalanced data

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Sivasankaran, A., Cherkassky, V., Albrecht, M., Williams, E., & Maiers, M. (2016). Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM. In Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015 (pp. 831-836). Article 7424425 (Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICMLA.2015.166

Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM. / Sivasankaran, Adarsh; Cherkassky, Vladimir; Albrecht, Mark et al.
Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015. Institute of Electrical and Electronics Engineers Inc., 2016. p. 831-836 7424425 (Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sivasankaran, A, Cherkassky, V, Albrecht, M, Williams, E & Maiers, M 2016, Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM. in Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015., 7424425, Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015, Institute of Electrical and Electronics Engineers Inc., pp. 831-836, IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015, Miami, United States, 12/9/15. https://doi.org/10.1109/ICMLA.2015.166

Sivasankaran A, Cherkassky V, Albrecht M, Williams E, Maiers M. Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM. In Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015. Institute of Electrical and Electronics Engineers Inc. 2016. p. 831-836. 7424425. (Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015). doi: 10.1109/ICMLA.2015.166

Sivasankaran, Adarsh ; Cherkassky, Vladimir ; Albrecht, Mark et al. / Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM. Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 831-836 (Proceedings - 2015 IEEE 14th International Conference on Machine Learning and Applications, ICMLA 2015).

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Donor selection for hematopoietic stem cell transplant using cost-sensitive SVM

Abstract

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Keywords

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