Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus

Hoon Ki Min; Erika K. Ross; Hang Joon Jo; Shinho Cho; Megan L. Settell; Ju Ho Jeong; Penelope S. Duffy; Su Youne Chang; Kevin E. Bennet; Charles D. Blaha; Kendall H. Lee

doi:10.1523/JNEUROSCI.0403-16.2016

Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus

Hoon Ki Min, Erika K. Ross, Hang Joon Jo, Shinho Cho, Megan L. Settell, Ju Ho Jeong, Penelope S. Duffy, Su Youne Chang, Kevin E. Bennet, Charles D. Blaha, Kendall H. Lee

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson’s disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen. We conducted DBS with miniature, scaled-to-animal size, multicontact electrodes and used functional magnetic resonance imaging to identify the best dopamine recording site in the brains of nonhuman primates (rhesus macaques), which are highly representative of human brain anatomy and circuitry. Real-time stimulation-evoked dopamine release was monitored using in vivo fast-scan cyclic voltammetry. This study demon-strates that STN DBS-evoked dopamine release can be reduced or increased by redirecting STN stimulation to a slightly different site.

Original language	English (US)
Pages (from-to)	6022-6029
Number of pages	8
Journal	Journal of Neuroscience
Volume	36
Issue number	22
DOIs	https://doi.org/10.1523/JNEUROSCI.0403-16.2016
State	Published - Jun 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (NIH; R01 NS 70872, to K.H.L.) and The Grainger Foundation. We thank Andrea McConico, Michael Marsh, Jill Anderson, Kip Ludwig, and Allan Bieber for their support and advices; Steve Goerss, Bruce Kall, and Seong Rok Han for their surgical support; Dong-Pyo Jang and Yoonbae Oh for their advice on electrochemistry; Kendall Dennis, Bruce Gustine, and their colleagues at the Mayo Clinic Division of Engineering for their support; Jodi Silvernail and the Mayo Clinic Department of Comparative Medicine for animal care; and Diane Sauter and the Mayo Clinic Center for Advanced Imaging Research at the Mayo Clinic for their support (NIH C06 RR018898).

Publisher Copyright:
© 2016 Min, Ross et al.

Keywords

Caudate
Deep brain stimulation
Dopamine
Fast-scan cyclic voltammetry
Functional magnetic resonance imaging
Subthalamic nucleus

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title = "Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus",

abstract = "Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson{\textquoteright}s disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen. We conducted DBS with miniature, scaled-to-animal size, multicontact electrodes and used functional magnetic resonance imaging to identify the best dopamine recording site in the brains of nonhuman primates (rhesus macaques), which are highly representative of human brain anatomy and circuitry. Real-time stimulation-evoked dopamine release was monitored using in vivo fast-scan cyclic voltammetry. This study demon-strates that STN DBS-evoked dopamine release can be reduced or increased by redirecting STN stimulation to a slightly different site.",

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AU - Bennet, Kevin E.

AU - Blaha, Charles D.

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Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus

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Keywords

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