TY - JOUR
T1 - Dose-dependent effect of statins on the incidence of acute kidney injury after cardiac surgery
AU - Mithani, Salima
AU - Kuskowski, Michael
AU - Slinin, Yelena
AU - Ishani, Areef
AU - McFalls, Edward
AU - Adabag, Selcuk
PY - 2011/2
Y1 - 2011/2
N2 - Background Acute kidney injury (AKI) after cardiac surgery is associated with increased morbidity and mortality. Methods We assessed whether statin treatment is associated with a lower incidence of postoperative AKI in 2,104 consecutive patients who underwent coronary artery bypass graft or valve surgery at the Minneapolis Veterans Administration Medical Center. Acute kidney injury was defined as absolute increase greater than 0.3 mg/dL or relative increase greater than 50% in serum creatinine from baseline, within 48 hours after surgery or requiring postoperative hemodialysis per AKI network. Propensity scores were utilized to adjust for the differences between the statin and the no-statin treatment groups. All statins were converted to equivalent-dose simvastatin and divided at the median to construct high-dose (<40 mg) and low-dose (<40 mg) statin groups. Results Of the 2,104 patients, 1,435 (68%) were taking statins (638 high-dose) and 495 (24%) developed AKI (25% high-dose vs 40% low-dose vs 35% no-statin; p = 0.014). Estimated preoperative glomerular filtration rate (p = 0.003), diabetes mellitus (p=0.02), valve surgery with or without coronary artery bypass graft (p = 0.024), cardiopulmonary bypass time (p = 0.001), and intraaortic balloon pump (p = 0.055) were independent predictors of AKI. After propensity adjustment statin treatment was not associated with postoperative AKI (odds ratio 0.79; 95% confidence interval 0.59 to 1.06; p = 0.11 for high-dose v. no-statin). After full adjustment for all independent predictors of AKI, the results did not change. Statins also had no effect on the incidence of postoperative hemodialysis (0.8% high-dose vs 1.9% low-dose vs 1% no-statin; p = 0.15). Conclusions Statin treatment is not associated with a lower incidence of AKI after cardiac surgery.
AB - Background Acute kidney injury (AKI) after cardiac surgery is associated with increased morbidity and mortality. Methods We assessed whether statin treatment is associated with a lower incidence of postoperative AKI in 2,104 consecutive patients who underwent coronary artery bypass graft or valve surgery at the Minneapolis Veterans Administration Medical Center. Acute kidney injury was defined as absolute increase greater than 0.3 mg/dL or relative increase greater than 50% in serum creatinine from baseline, within 48 hours after surgery or requiring postoperative hemodialysis per AKI network. Propensity scores were utilized to adjust for the differences between the statin and the no-statin treatment groups. All statins were converted to equivalent-dose simvastatin and divided at the median to construct high-dose (<40 mg) and low-dose (<40 mg) statin groups. Results Of the 2,104 patients, 1,435 (68%) were taking statins (638 high-dose) and 495 (24%) developed AKI (25% high-dose vs 40% low-dose vs 35% no-statin; p = 0.014). Estimated preoperative glomerular filtration rate (p = 0.003), diabetes mellitus (p=0.02), valve surgery with or without coronary artery bypass graft (p = 0.024), cardiopulmonary bypass time (p = 0.001), and intraaortic balloon pump (p = 0.055) were independent predictors of AKI. After propensity adjustment statin treatment was not associated with postoperative AKI (odds ratio 0.79; 95% confidence interval 0.59 to 1.06; p = 0.11 for high-dose v. no-statin). After full adjustment for all independent predictors of AKI, the results did not change. Statins also had no effect on the incidence of postoperative hemodialysis (0.8% high-dose vs 1.9% low-dose vs 1% no-statin; p = 0.15). Conclusions Statin treatment is not associated with a lower incidence of AKI after cardiac surgery.
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U2 - 10.1016/j.athoracsur.2010.10.061
DO - 10.1016/j.athoracsur.2010.10.061
M3 - Article
C2 - 21256305
AN - SCOPUS:78751668526
SN - 0003-4975
VL - 91
SP - 520
EP - 525
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 2
ER -