Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient with Kidney Transplant

Percy Guanzon Balderia; Aditya Chandorkar; Yongwoo Kim; Soumya Patnaik; Joshua Sloan; George Charles Newman

doi:10.1097/PTS.0000000000000225

Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient with Kidney Transplant

Percy Guanzon Balderia, Aditya Chandorkar, Yongwoo Kim, Soumya Patnaik, Joshua Sloan, George Charles Newman

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7 Scopus citations

Abstract

Dosing cefepime for renal function does not completely prevent neurotoxicity in a kidney transplant patient. Cefepime neurotoxicity has been reported primarily among patients with renal insufficiency who received standard doses of the antibiotic. We report a case of nonconvulsive status epilepticus from dose-adjusted cefepime in a kidney transplant patient. The timing of symptoms along with clinical and electroencephalographic improvement after discontinuation of cefepime was critical to the diagnosis. Whether we should adjust the dose of cefepime differently in a patient with transplanted kidney to prevent neurotoxicity is unknown.

Original language	English (US)
Pages (from-to)	e33-e34
Journal	Journal of Patient Safety
Volume	14
Issue number	2
DOIs	https://doi.org/10.1097/PTS.0000000000000225
State	Published - Jun 1 2018
Externally published	Yes

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© 2015 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

cefepime
encephalopathy
seizures
transplants

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AU - Sloan, Joshua

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Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient with Kidney Transplant

Abstract

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