DQ β sequences in HLA-DR4 haplotypes

J. M. Hilden; J. M. Curtsinger; J. S. Cairns; F. H. Bach

doi:10.1016/0198-8859(87)90073-5

DQ β sequences in HLA-DR4 haplotypes

J. M. Hilden, J. M. Curtsinger, J. S. Cairns, F. H. Bach

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Abstract

A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.

Original language	English (US)
Pages (from-to)	261-264
Number of pages	4
Journal	Human Immunology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/0198-8859(87)90073-5
State	Published - Apr 1987
Externally published	Yes

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abstract = "A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.",

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AU - Curtsinger, J. M.

AU - Cairns, J. S.

AU - Bach, F. H.

PY - 1987/4

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AB - A cDNA clone encoding the entire mature DQ β chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ β sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ β sequence polymorphism within this serotype (to date, DQ β sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.

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JO - Human Immunology

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DQ β sequences in HLA-DR4 haplotypes

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