Drosophila heparan sulfate 6-o-endosulfatase sulf1 facilitates wingless (Wg) protein degradation

Adam Kleinschmit, Masahiko Takemura, Katsufumi Dejima, Pui Yee Choi, Hiroshi Nakato

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Heparan sulfate 6-O-endosulfatases (Sulfs) have opposite effects on Wnt signaling in vertebrates and Drosophila systems. Results: Sulf1 expression in Drosophila leads to Wingless degradation. Conclusion: Vertebrate and Drosophila Sulfs have an intrinsically similar enzymatic activity, but exert different effects on Wnt/Wg signaling in a context-dependent manner. Significance: This finding contributes to the understanding of extracellular regulation of Wnt/Wg signaling.

Original languageEnglish (US)
Pages (from-to)5081-5089
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - Feb 15 2013

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