TY - JOUR
T1 - Drug-eluting stent coatings
AU - Puskas, Judit E.
AU - Muñoz-Robledo, Lyn G.
AU - Hoerr, Robert A.
AU - Foley, John
AU - Schmidt, Steven P.
AU - Evancho-Chapman, Michelle
AU - Dong, Jinping
AU - Frethem, Chris
AU - Haugstad, Greg
PY - 2009
Y1 - 2009
N2 - This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug-eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Ourgroup has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.TM) was used to coat test coupons and coronary stents with selected DSIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer-drug mixture.
AB - This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug-eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Ourgroup has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.TM) was used to coat test coupons and coronary stents with selected DSIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer-drug mixture.
UR - http://www.scopus.com/inward/record.url?scp=74049119439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74049119439&partnerID=8YFLogxK
U2 - 10.1002/wnan.38
DO - 10.1002/wnan.38
M3 - Review article
C2 - 20049810
AN - SCOPUS:74049119439
SN - 1939-5116
VL - 1
SP - 451
EP - 462
JO - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
IS - 4
ER -