Drug-eluting stent coatings

Judit E. Puskas, Lyn G. Muñoz-Robledo, Robert A. Hoerr, John Foley, Steven P. Schmidt, Michelle Evancho-Chapman, Jinping Dong, Chris Frethem, Greg Haugstad

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug-eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Ourgroup has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.TM) was used to coat test coupons and coronary stents with selected DSIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer-drug mixture.

Original languageEnglish (US)
Pages (from-to)451-462
Number of pages12
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume1
Issue number4
DOIs
StatePublished - 2009

Fingerprint

Dive into the research topics of 'Drug-eluting stent coatings'. Together they form a unique fingerprint.

Cite this