TY - JOUR
T1 - Drug-induced mitochondrial toxicity in the geriatric population
T2 - Challenges and future directions
AU - Will, Yvonne
AU - Shields, Jefry E.
AU - Wallace, Kendall B.
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/6
Y1 - 2019/6
N2 - Mitochondrial function declines with age, leading to a variety of age-related diseases (metabolic, central nervous system-related, cancer, etc.) and medication usage increases with age due to the increase in diseases. Drug-induced mitochondrial toxicity has been described for many different drug classes and can lead to liver, muscle, kidney and central nervous system injury and, in rare cases, to death. Many of the most prescribed medications in the geriatric population carry mitochondrial liabilities. We have demonstrated that, over the past decade, each class of drugs that demonstrated mitochondrial toxicity contained drugs with both more and less adverse effects on mitochondria. As patient treatment is often essential, we suggest using medication(s) with the best safety profile and the avoidance of concurrent usage of multiple medications that carry mitochondrial liabilities. In addition, we also recommend lifestyle changes to further improve one’s mitochondrial function, such as weight loss, exercise and nutrition.
AB - Mitochondrial function declines with age, leading to a variety of age-related diseases (metabolic, central nervous system-related, cancer, etc.) and medication usage increases with age due to the increase in diseases. Drug-induced mitochondrial toxicity has been described for many different drug classes and can lead to liver, muscle, kidney and central nervous system injury and, in rare cases, to death. Many of the most prescribed medications in the geriatric population carry mitochondrial liabilities. We have demonstrated that, over the past decade, each class of drugs that demonstrated mitochondrial toxicity contained drugs with both more and less adverse effects on mitochondria. As patient treatment is often essential, we suggest using medication(s) with the best safety profile and the avoidance of concurrent usage of multiple medications that carry mitochondrial liabilities. In addition, we also recommend lifestyle changes to further improve one’s mitochondrial function, such as weight loss, exercise and nutrition.
KW - Aging
KW - Drug-induced mitochondrial toxicity
KW - Polypharmacy
UR - http://www.scopus.com/inward/record.url?scp=85068505246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068505246&partnerID=8YFLogxK
U2 - 10.3390/biology8020032
DO - 10.3390/biology8020032
M3 - Review article
C2 - 31083551
AN - SCOPUS:85068505246
SN - 2079-7737
VL - 8
JO - Biology
JF - Biology
IS - 2
M1 - 32
ER -