Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression

Medicine & Life Sciences

• Everolimus 100%
• Neuroendocrine Tumors 89%
• TOR Serine-Threonine Kinases 88%
• Phosphatidylinositol 3-Kinase 80%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52%
• PD 0325901 15%
• Mechanistic Target of Rapamycin Complex 1 11%
• Neoplasm Metastasis 10%
• Protein Kinase Inhibitors 9%
• Liver 9%
• Growth 8%
• Mitogen-Activated Protein Kinases 8%
• Nude Mice 8%
• Progression-Free Survival 8%
• Cell Biology 7%
• Up-Regulation 6%
• Western Blotting 6%
• Cell Proliferation 5%
• Therapeutics 5%
• Cell Line 5%
• Drug Therapy 5%
• Injections 5%
• Survival 4%
• In Vitro Techniques 3%