Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin

Lixia Ren, Lihong He, Tongchen Sun, Xia Dong, Yongming Chen, Jin Huang, Chun Wang

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with α-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)902-910
Number of pages9
JournalMacromolecular Bioscience
Volume9
Issue number9
DOIs
StatePublished - Sep 9 2009

Keywords

  • Cyclodextrins
  • Drug delivery
  • Grafted copolymers
  • Hydrogels
  • Stimulus responsive

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