Dual-Stimulus-Triggered Programmable Drug Release and Luminescent Ratiometric pH Sensing from Chemically Stable Biocompatible Zinc Metal-Organic Framework

Kai Xing, Ruiqing Fan, Fengyou Wang, Huan Nie, Xi Du, Shuang Gai, Ping Wang, Yulin Yang

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Metal-organic frameworks (MOFs), as drug delivery carriers, with high loading capacity and controllable release behavior can provide a more efficacious therapy in cancer treatments. In our work, a novel biocompatible zinc MOF Zn-cpon-1 with the (3,6)-connected rtl 3D topological network was designed and synthesized via employing ClO4- anion as template. The optically and chemically stable Zn-cpon-1 could be verified as a pH-responsive dual-emission platform and excellent drug delivery carrier with higher 5-fluorouracil (5-FU) (44.75 wt %) loading behavior than 6-mercaptopurine (6-MP) (4.79 wt %) ascribed to the influence of size and shape matching. The multiple interactions between Zn-cpon-1 and 5-FU drug molecules have been discussed and evidenced, which could be quantitatively estimated via the rate constant related to the topological structure. Specially, the gust release behavior of 5-FU@Zn-cpon-1 microcrystal was described and programmed via the Weibull distribution model and could be dual-triggered by the temperature and pH stimulus. This study illustrates that the Zn-cpon-1 without any postmodification performs a favorable potential of being used as biomedical drug delivery alternative carriers in effective drug payload, flexible release administration, and superior dual-stimuli responsiveness.

Original languageEnglish (US)
Pages (from-to)22746-22756
Number of pages11
JournalACS Applied Materials and Interfaces
Volume10
Issue number26
DOIs
StatePublished - Jul 5 2018
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by National Key R&D Program of China (2017YFB1300104) and the National Natural Science Foundation of China (grant 21371040 and 21571042).

Keywords

  • drug delivery
  • dual-stimuli responsive release
  • metalaorganic frameworks
  • programming kinetics
  • ratiometric luminescence

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