Dyslipidemia and its management after renal transplantation

Bertram L. Kasiske

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Dyslipidemias are common after renal transplantation. Most common are elevations in total and low-density lipoprotein cholesterol. Causes of dyslipidemia are usually multiple, but include immunosuppression (especially prednisone, cyclosporine and sirolimus), graft dysfunction (reduced glomerular nitration rate and proteinuria), and genetic predisposition. There is a growing amount of evidence suggesting that dyslipidemias contribute to the very high incidence of cardiovascular disease after transplantation. Less well established is whether the associations between dyslipidemias and graft dysfunction are due to a causal role of lipid abnormalities on renal injury. In any case, hypercholesterolemia, and especially increases in low density lipoprotein cholesterol, should be treated using guidelines established for patients in the general population.

Original languageEnglish (US)
Pages (from-to)S81-S88
JournalJournal of Nephrology
Volume14
Issue number4 SUPPL.
StatePublished - Dec 1 2001

Keywords

  • Cardiovascular disease
  • Chronic allograft nephropathy
  • Chronic rejection
  • HMG-CoA reductase inhibitors
  • Hypercholesterolemia

Fingerprint Dive into the research topics of 'Dyslipidemia and its management after renal transplantation'. Together they form a unique fingerprint.

Cite this