TY - JOUR
T1 - Dyslipidemia and its management after renal transplantation
AU - Kasiske, Bertram L.
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Dyslipidemias are common after renal transplantation. Most common are elevations in total and low-density lipoprotein cholesterol. Causes of dyslipidemia are usually multiple, but include immunosuppression (especially prednisone, cyclosporine and sirolimus), graft dysfunction (reduced glomerular nitration rate and proteinuria), and genetic predisposition. There is a growing amount of evidence suggesting that dyslipidemias contribute to the very high incidence of cardiovascular disease after transplantation. Less well established is whether the associations between dyslipidemias and graft dysfunction are due to a causal role of lipid abnormalities on renal injury. In any case, hypercholesterolemia, and especially increases in low density lipoprotein cholesterol, should be treated using guidelines established for patients in the general population.
AB - Dyslipidemias are common after renal transplantation. Most common are elevations in total and low-density lipoprotein cholesterol. Causes of dyslipidemia are usually multiple, but include immunosuppression (especially prednisone, cyclosporine and sirolimus), graft dysfunction (reduced glomerular nitration rate and proteinuria), and genetic predisposition. There is a growing amount of evidence suggesting that dyslipidemias contribute to the very high incidence of cardiovascular disease after transplantation. Less well established is whether the associations between dyslipidemias and graft dysfunction are due to a causal role of lipid abnormalities on renal injury. In any case, hypercholesterolemia, and especially increases in low density lipoprotein cholesterol, should be treated using guidelines established for patients in the general population.
KW - Cardiovascular disease
KW - Chronic allograft nephropathy
KW - Chronic rejection
KW - HMG-CoA reductase inhibitors
KW - Hypercholesterolemia
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M3 - Article
C2 - 11798152
AN - SCOPUS:0013419195
SN - 1121-8428
VL - 14
SP - S81-S88
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 4 SUPPL.
ER -