Abstract
A loss of T cell tolerance underlies the development of most autoimmune diseases. The design of therapeutic strategies to re-institute immune tolerance, however, is hampered by uncertainty regarding the molecular mechanisms involved in the inactivation of potentially autoreactive T cells. Recently, E3 ubiquitin ligases have been shown to mediate the development of a durable state of unresponsiveness in T cells called clonal anergy. In this review, we will discuss the mechanisms used by E3 ligases to control the activation of T cells and prevent the development of autoimmunity.
Original language | English (US) |
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Pages (from-to) | 233-242 |
Number of pages | 10 |
Journal | Arthritis Research and Therapy |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2005 |