Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy

Diana L. Ross; Kenneth F Swaiman; Fernando Torres; Jessie Hansen

doi:10.1016/0887-8994(85)90045-1

Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy

Diana L. Ross, Kenneth F Swaiman, Fernando Torres, Jessie Hansen

Neurology

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Abstract

Early changes in blood chemistry and the electroencephalogram were monitored during the first three hours after initiating the medium chain triglyceride (MCT) diet in nine children with intractable atypical absence seizures. Serum glucose, insulin, triglycerides, cholesterol, free fatty acids, ketone bodies concentrations, and venous pH were assayed before and at timed intervals after MCT oil was administered orally. The concentration of serum ketones rose progressively over three hours, β-hydroxybutyrate proportionately higher than acetoacetate. A statistically significant decrease in the group mean number of epileptiform discharges occurred following MCT therapy. Seizure frequency decreased by more than 50 percent in two-thirds of the children during the 10 week treatment period.

Original language	English (US)
Pages (from-to)	104-108
Number of pages	5
Journal	Pediatric Neurology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/0887-8994(85)90045-1
State	Published - 1985

Bibliographical note

Funding Information:
This research was supported in part by National Institutes of Health contract No. 1-NS-5-2327.

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title = "Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy",

abstract = "Early changes in blood chemistry and the electroencephalogram were monitored during the first three hours after initiating the medium chain triglyceride (MCT) diet in nine children with intractable atypical absence seizures. Serum glucose, insulin, triglycerides, cholesterol, free fatty acids, ketone bodies concentrations, and venous pH were assayed before and at timed intervals after MCT oil was administered orally. The concentration of serum ketones rose progressively over three hours, β-hydroxybutyrate proportionately higher than acetoacetate. A statistically significant decrease in the group mean number of epileptiform discharges occurred following MCT therapy. Seizure frequency decreased by more than 50 percent in two-thirds of the children during the 10 week treatment period.",

author = "Ross, {Diana L.} and Swaiman, {Kenneth F} and Fernando Torres and Jessie Hansen",

note = "Funding Information: This research was supported in part by National Institutes of Health contract No. 1-NS-5-2327.",

year = "1985",

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T1 - Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy

AU - Ross, Diana L.

AU - Swaiman, Kenneth F

AU - Torres, Fernando

AU - Hansen, Jessie

N1 - Funding Information: This research was supported in part by National Institutes of Health contract No. 1-NS-5-2327.

PY - 1985

Y1 - 1985

N2 - Early changes in blood chemistry and the electroencephalogram were monitored during the first three hours after initiating the medium chain triglyceride (MCT) diet in nine children with intractable atypical absence seizures. Serum glucose, insulin, triglycerides, cholesterol, free fatty acids, ketone bodies concentrations, and venous pH were assayed before and at timed intervals after MCT oil was administered orally. The concentration of serum ketones rose progressively over three hours, β-hydroxybutyrate proportionately higher than acetoacetate. A statistically significant decrease in the group mean number of epileptiform discharges occurred following MCT therapy. Seizure frequency decreased by more than 50 percent in two-thirds of the children during the 10 week treatment period.

AB - Early changes in blood chemistry and the electroencephalogram were monitored during the first three hours after initiating the medium chain triglyceride (MCT) diet in nine children with intractable atypical absence seizures. Serum glucose, insulin, triglycerides, cholesterol, free fatty acids, ketone bodies concentrations, and venous pH were assayed before and at timed intervals after MCT oil was administered orally. The concentration of serum ketones rose progressively over three hours, β-hydroxybutyrate proportionately higher than acetoacetate. A statistically significant decrease in the group mean number of epileptiform discharges occurred following MCT therapy. Seizure frequency decreased by more than 50 percent in two-thirds of the children during the 10 week treatment period.

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Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy

Abstract

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