TY - JOUR
T1 - Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance
AU - Molin Netto, Bárbara Dal
AU - Earthman, Carrie P.
AU - Cravo Bettini, Solange
AU - Grotti Clemente, Ana Paula
AU - Landi Masquio, Deborah Cristina
AU - Farias, Gisele
AU - Boritza, Katia
AU - da Silva, Larissa Gabrielle
AU - von der Heyde, Maria Emilia
AU - Dâmaso, Ana Raimunda
N1 - Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Introduction Body weight varies depending on the prevailing direction of environmental pressures; however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3±6.4 to 31.7±5.7 kg/m 2 (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2±25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB.
AB - Introduction Body weight varies depending on the prevailing direction of environmental pressures; however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3±6.4 to 31.7±5.7 kg/m 2 (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2±25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB.
KW - energy regulation
KW - gastric bypass
KW - gastrointestinal hormones
KW - neuropeptides
KW - obesity
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U2 - 10.1097/MEG.0000000000000665
DO - 10.1097/MEG.0000000000000665
M3 - Article
C2 - 27203601
AN - SCOPUS:84969685633
SN - 0954-691X
VL - 28
SP - 1050
EP - 1055
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 9
ER -