Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance

Bárbara Dal Molin Netto, Carrie P. Earthman, Solange Cravo Bettini, Ana Paula Grotti Clemente, Deborah Cristina Landi Masquio, Gisele Farias, Katia Boritza, Larissa Gabrielle da Silva, Maria Emilia von der Heyde, Ana Raimunda Dâmaso

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7 Scopus citations


Introduction Body weight varies depending on the prevailing direction of environmental pressures; however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3±6.4 to 31.7±5.7 kg/m 2 (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2±25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB.

Original languageEnglish (US)
Pages (from-to)1050-1055
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number9
StatePublished - Sep 1 2016

Bibliographical note

Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


  • energy regulation
  • gastric bypass
  • gastrointestinal hormones
  • neuropeptides
  • obesity


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