TY - JOUR
T1 - Early emphysematous changes in asymptomatic smokers
T2 - Detection with 3He MR imaging
AU - Fain, Sean B.
AU - Panth, Shilpa R.
AU - Evans, Michael D.
AU - Wentland, Andrew L.
AU - Holmes, James H.
AU - Korosec, Frank R.
AU - O'Brien, Matthew J.
AU - Fountaine, Harvey
AU - Grist, Thomas M.
PY - 2006/6
Y1 - 2006/6
N2 - Purpose: To prospectively compare apparent diffusion coefficient (ADC) measurements derived from diffusion-weighted hyperpolarized helium 3 ( 3He) magnetic resonance (MR) imaging with functional and structural findings using spirometric tests and thin-section computed tomography (CT) of the lungs in asymptomatic smokers and healthy non-smokers of similar age. Materials and: Methods: All studies were HIPAA compliant and were approved by the institutional review board. Informed consent was obtained. Ventilation and diffusion-weighted 3He MR images were obtained in healthy subjects: 11 smokers (five women, six men; mean age, 47 years ± 18 [standard deviation]; range, 23-73 years) and eight nonsmokers (<100 cigarettes in lifetime) (four women, four men; mean age, 46 years ± 16; range, 23-69 years). Mean ADC values for smokers and nonsmokers were compared with spirometric values, diffusing capacity of the lung for carbon monoxide (DLCO), age, and pack-years with Spearman rank correlation coefficient (rs) and multiple linear regression analysis. Mean ADC value and thin-section CT emphysema index of relative area less than-950 HU (RA950) were compared on a regional basis by using linear mixed-effect models. Results: Mean ADC values and number of pack-years were significantly correlated (rs = 0.60; 95% confidence interval (CI): 0.21, 1.00; P = .007); relationship remained significant after adjustment for age (P = .003). DLCO was strongly correlated with pack-years (rs = -0.63; 95% CI: -0.97, -0.29; P = .004). Negative correlations between mean ADC values and percentage predicted DLCO (rs = -0.79; 95% CI: -0.93, -0.64; P < .001) and the ratio of forced expiratory volume in 1 second to forced vital capacity (rs = -0.72; 95% CI: -0.92, -0.52; P = .001) were statistically significant. Correlations between spirometric values or RA950 and number of pack-years were not significant (.05 level). Conclusion: Correlations between mean ADC values and pulmonary function test measurements for diagnosing emphysema, especially DLCO, were statistically significant.
AB - Purpose: To prospectively compare apparent diffusion coefficient (ADC) measurements derived from diffusion-weighted hyperpolarized helium 3 ( 3He) magnetic resonance (MR) imaging with functional and structural findings using spirometric tests and thin-section computed tomography (CT) of the lungs in asymptomatic smokers and healthy non-smokers of similar age. Materials and: Methods: All studies were HIPAA compliant and were approved by the institutional review board. Informed consent was obtained. Ventilation and diffusion-weighted 3He MR images were obtained in healthy subjects: 11 smokers (five women, six men; mean age, 47 years ± 18 [standard deviation]; range, 23-73 years) and eight nonsmokers (<100 cigarettes in lifetime) (four women, four men; mean age, 46 years ± 16; range, 23-69 years). Mean ADC values for smokers and nonsmokers were compared with spirometric values, diffusing capacity of the lung for carbon monoxide (DLCO), age, and pack-years with Spearman rank correlation coefficient (rs) and multiple linear regression analysis. Mean ADC value and thin-section CT emphysema index of relative area less than-950 HU (RA950) were compared on a regional basis by using linear mixed-effect models. Results: Mean ADC values and number of pack-years were significantly correlated (rs = 0.60; 95% confidence interval (CI): 0.21, 1.00; P = .007); relationship remained significant after adjustment for age (P = .003). DLCO was strongly correlated with pack-years (rs = -0.63; 95% CI: -0.97, -0.29; P = .004). Negative correlations between mean ADC values and percentage predicted DLCO (rs = -0.79; 95% CI: -0.93, -0.64; P < .001) and the ratio of forced expiratory volume in 1 second to forced vital capacity (rs = -0.72; 95% CI: -0.92, -0.52; P = .001) were statistically significant. Correlations between spirometric values or RA950 and number of pack-years were not significant (.05 level). Conclusion: Correlations between mean ADC values and pulmonary function test measurements for diagnosing emphysema, especially DLCO, were statistically significant.
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U2 - 10.1148/radiol.2393050111
DO - 10.1148/radiol.2393050111
M3 - Review article
C2 - 16714465
AN - SCOPUS:33744826801
SN - 0033-8419
VL - 239
SP - 875
EP - 883
JO - Radiology
JF - Radiology
IS - 3
ER -