Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes

Mikaela P. Cadiz; Mackenzie R. Schara; Bailey H. Kemp; Rachel M.Gibbons Johnson

doi:10.1089/jmf.2019.0065

Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes

Mikaela P. Cadiz, Mackenzie R. Schara, Bailey H. Kemp, Rachel M.Gibbons Johnson

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Echinacea purpurea is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of E. purpurea root extract on the survival of concanavalin A (ConA)-Activated murine splenocytes and the production of the cytokines interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor (TNF) by these cells. We found that E. purpurea root extract did not affect splenocyte survival or IL-2 production and increased IFN-γcytokine levels only modestly. However, TNF cytokine production by ConA-Activated splenocytes increased in response to E. purpurea root extract treatment in a dose-dependent manner, suggesting that E. purpurea root extract does have immunomodulatory effects.

Original language	English (US)
Pages (from-to)	1146-1150
Number of pages	5
Journal	Journal of Medicinal Food
Volume	22
Issue number	11
DOIs	https://doi.org/10.1089/jmf.2019.0065
State	Published - Nov 2019

Bibliographical note

Funding Information:
This work was supported by the University of Minnesota Undergraduate Research Opportunity Program and the Office of the Vice President for Research of the University of Minnesota (UMM Faculty Enhancement Research Fund).

Publisher Copyright:
© Copyright 2019, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2019.

Keywords

cytokines
herbal supplement
immunomodulation

Access

10.1089/jmf.2019.0065

OpenUrl availability

Full text

Cite this

@article{9a51cdb5c79c4059961c9d5511354102,

title = "Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes",

abstract = "Echinacea purpurea is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of E. purpurea root extract on the survival of concanavalin A (ConA)-Activated murine splenocytes and the production of the cytokines interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor (TNF) by these cells. We found that E. purpurea root extract did not affect splenocyte survival or IL-2 production and increased IFN-γcytokine levels only modestly. However, TNF cytokine production by ConA-Activated splenocytes increased in response to E. purpurea root extract treatment in a dose-dependent manner, suggesting that E. purpurea root extract does have immunomodulatory effects.",

keywords = "cytokines, herbal supplement, immunomodulation",

author = "Cadiz, {Mikaela P.} and Schara, {Mackenzie R.} and Kemp, {Bailey H.} and Johnson, {Rachel M.Gibbons}",

note = "Funding Information: This work was supported by the University of Minnesota Undergraduate Research Opportunity Program and the Office of the Vice President for Research of the University of Minnesota (UMM Faculty Enhancement Research Fund). Publisher Copyright: {\textcopyright} Copyright 2019, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2019.",

year = "2019",

month = nov,

doi = "10.1089/jmf.2019.0065",

language = "English (US)",

volume = "22",

pages = "1146--1150",

journal = "Journal of Medicinal Food",

issn = "1096-620X",

publisher = "Mary Ann Liebert Inc.",

number = "11",

}

TY - JOUR

T1 - Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes

AU - Cadiz, Mikaela P.

AU - Schara, Mackenzie R.

AU - Kemp, Bailey H.

AU - Johnson, Rachel M.Gibbons

N1 - Funding Information: This work was supported by the University of Minnesota Undergraduate Research Opportunity Program and the Office of the Vice President for Research of the University of Minnesota (UMM Faculty Enhancement Research Fund). Publisher Copyright: © Copyright 2019, Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition 2019.

PY - 2019/11

Y1 - 2019/11

N2 - Echinacea purpurea is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of E. purpurea root extract on the survival of concanavalin A (ConA)-Activated murine splenocytes and the production of the cytokines interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor (TNF) by these cells. We found that E. purpurea root extract did not affect splenocyte survival or IL-2 production and increased IFN-γcytokine levels only modestly. However, TNF cytokine production by ConA-Activated splenocytes increased in response to E. purpurea root extract treatment in a dose-dependent manner, suggesting that E. purpurea root extract does have immunomodulatory effects.

AB - Echinacea purpurea is a common herbal remedy used to treat a variety of illnesses, though its health benefits and effects on the immune system have not been fully elucidated. In this study, we investigated the effect of E. purpurea root extract on the survival of concanavalin A (ConA)-Activated murine splenocytes and the production of the cytokines interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor (TNF) by these cells. We found that E. purpurea root extract did not affect splenocyte survival or IL-2 production and increased IFN-γcytokine levels only modestly. However, TNF cytokine production by ConA-Activated splenocytes increased in response to E. purpurea root extract treatment in a dose-dependent manner, suggesting that E. purpurea root extract does have immunomodulatory effects.

KW - cytokines

KW - herbal supplement

KW - immunomodulation

UR - http://www.scopus.com/inward/record.url?scp=85075090581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075090581&partnerID=8YFLogxK

U2 - 10.1089/jmf.2019.0065

DO - 10.1089/jmf.2019.0065

M3 - Article

C2 - 31274384

AN - SCOPUS:85075090581

SN - 1096-620X

VL - 22

SP - 1146

EP - 1150

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

IS - 11

ER -

Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this