The aim of this study was to examine brain dynamics during video game play by means of electrophysiological brain mapping. We have conducted a pilot experimental study on healthy young human subjects during video game play. High resolution EEG (64-ch or 128-ch) was obtained to detect and monitor electroencephalograms (EEG) on the scalp of the subjects. Electrophysiological recordings were made prior to and during video game play over segments of a total duration of up to 2 hours, with 3 min. long segments. Spectral analysis was performed on each of the recorded segments to extract the theta rhythm (4-8 Hz) to examine the modulatory effects of long-lasting game play and the dynamic changes of spectral contribution in the theta-wave range. The percent changes in the theta-waves were computed in reference to the baseline (which was recorded prior to game play). The present pilot results suggest that a) the frontal lobe exhibits strong theta activity during video game play; b) the frontal midline theta-wave activity increases over time relative to the eye open resting condition. These results suggest that long, continuous periods of video game play increase the mental load on the players, which may have mental health implications.