Effect of 6-hydroxydopamine on the incorporation of 14C-leucine into rat brain protein

Horace H. Loh, S. Stolman, C. Y. Lee

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The effect of 6-hydroxydopamine on in vitro and in vivo cerebral protein synthesis was studied in rats. Male rats receiving 200 μg of 6-hydroxydopamine intracisternally daily for three injections showed a significant decrease in incorporating activity of 14C-leucine into brain microsomal and synaptosomal proteins over that of control animals in vitro. Experiments with intracisternally injected 14C-leucine also showed a decreased incorporation of labeled amino acid in 6-hydroxydopamine treated animals in mitochondria, crude nuclei, "noncholinergic" synaptosome and myelin fraction, while no change was demonstrated in the other fractions. The degeneration of adrenergic nerve endings by 6-hydroxydopamine may be related to its inhibitory action on brain protein synthesis.

Original languageEnglish (US)
Pages (from-to)1171-1180
Number of pages10
JournalLife Sciences
Issue number20 PART 1
StatePublished - Oct 15 1971


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