Effect of Angiotensin II Blockade on Dietary Protein-Induced Renal Growth

Lawrence J. Smith, Mark E. Rosenberg, Thomas H. Hostetter

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Dietary protein provokes renal growth and synthesis of renin. Because angiotensin II (AII) has growth-promoting properties, we tested the possibility that protein-induced renal growth depends on angiotensin II. Normal adult male rats placed on a high-protein diet (50%) developed significant renal and glomerular growth over 6 days compared with rats on a low-protein diet (6%). However, neither angiotensin converting enzyme inhibition with enalapril nor angiotensin receptor antagonism with losartan influenced the degree of whole-kidney, cortical tubular, or glomerular growth. Thus, angiotensin II is not a necessary factor in dietary protein-induced renal growth in normal adult rats.

Original languageEnglish (US)
Pages (from-to)120-127
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume22
Issue number1
DOIs
StatePublished - 1993

Bibliographical note

Funding Information:
From the Department of Medicine, Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN. Received November 2, 1992; accepted in revised form February 2, 1993, Supported by US Public Health Service Grants No. AM-31437 (T.H.H.) and 1229-DKH3075 (M.E.R.) and bya Young Investigator Grant from the National Kidney Foundation (M.E.R.). Address reprint requests to Thomas H. Hostetter, MD, Department of Medicine, Division of Renal Diseases and Hypertension, UMHC Box 736, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455. © 1993 by the National Kidney Foundation, Inc. 0272-6386/93/2201-0019$3.00/0

Keywords

  • Renin
  • angiotensin
  • dietary protein
  • renal growth

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