Abstract
Dietary protein provokes renal growth and synthesis of renin. Because angiotensin II (AII) has growth-promoting properties, we tested the possibility that protein-induced renal growth depends on angiotensin II. Normal adult male rats placed on a high-protein diet (50%) developed significant renal and glomerular growth over 6 days compared with rats on a low-protein diet (6%). However, neither angiotensin converting enzyme inhibition with enalapril nor angiotensin receptor antagonism with losartan influenced the degree of whole-kidney, cortical tubular, or glomerular growth. Thus, angiotensin II is not a necessary factor in dietary protein-induced renal growth in normal adult rats.
Original language | English (US) |
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Pages (from-to) | 120-127 |
Number of pages | 8 |
Journal | American Journal of Kidney Diseases |
Volume | 22 |
Issue number | 1 |
DOIs | |
State | Published - 1993 |
Keywords
- Renin
- angiotensin
- dietary protein
- renal growth