Dietary protein provokes renal growth and synthesis of renin. Because angiotensin II (AII) has growth-promoting properties, we tested the possibility that protein-induced renal growth depends on angiotensin II. Normal adult male rats placed on a high-protein diet (50%) developed significant renal and glomerular growth over 6 days compared with rats on a low-protein diet (6%). However, neither angiotensin converting enzyme inhibition with enalapril nor angiotensin receptor antagonism with losartan influenced the degree of whole-kidney, cortical tubular, or glomerular growth. Thus, angiotensin II is not a necessary factor in dietary protein-induced renal growth in normal adult rats.
Bibliographical noteFunding Information:
From the Department of Medicine, Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN. Received November 2, 1992; accepted in revised form February 2, 1993, Supported by US Public Health Service Grants No. AM-31437 (T.H.H.) and 1229-DKH3075 (M.E.R.) and bya Young Investigator Grant from the National Kidney Foundation (M.E.R.). Address reprint requests to Thomas H. Hostetter, MD, Department of Medicine, Division of Renal Diseases and Hypertension, UMHC Box 736, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455. © 1993 by the National Kidney Foundation, Inc. 0272-6386/93/2201-0019$3.00/0
- dietary protein
- renal growth