TY - JOUR
T1 - Effect of caffeine on the ventilatory response to inhaled carbon dioxide
AU - Pianosi, Paul
AU - Grondin, Danielle
AU - Desmond, Katherine
AU - Coates, Allan L.
AU - Aranda, Jacob V.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1994/3
Y1 - 1994/3
N2 - We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. PetCO2 and (V̇e), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the V̇e-PetCO2 response increased from 0.21 ± 0.14 to 0.38 ± 0.14 and from 0.23 ± 0.12 to 0.59 ± 0.45 VC·min-1·mmHg-1, measured by RB and SS respectively (P<0.05). Plotting Vt vs PetCO2 revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the Vt-PetCO2 relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO2 interaction is dependent on the methodology employed.
AB - We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. PetCO2 and (V̇e), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the V̇e-PetCO2 response increased from 0.21 ± 0.14 to 0.38 ± 0.14 and from 0.23 ± 0.12 to 0.59 ± 0.45 VC·min-1·mmHg-1, measured by RB and SS respectively (P<0.05). Plotting Vt vs PetCO2 revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the Vt-PetCO2 relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO2 interaction is dependent on the methodology employed.
KW - CO response
KW - Control of breathing
KW - Mammals
KW - Pharmacological agents
KW - caffeine
KW - humans
KW - steady state vs rebreathing
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U2 - 10.1016/0034-5687(94)90093-0
DO - 10.1016/0034-5687(94)90093-0
M3 - Article
C2 - 8059074
AN - SCOPUS:0028273537
SN - 0034-5687
VL - 95
SP - 311
EP - 320
JO - Respiration Physiology
JF - Respiration Physiology
IS - 3
ER -