Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression

C. Wang; C. J. Billington; A. S. Levine; C. M. Kotz

doi:10.1097/00001756-200009280-00040

Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression

C. Wang, C. J. Billington, A. S. Levine, C. M. Kotz

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Cocaine and amphetamine regulated transcript (CART) decreases feeding and body weight after ventricular injection. CART mRNA and peptide are found in the paraventricular nucleus of the hypothalamus (PVN). The purpose of the present study was to determine effects of PVN-injected CART on feeding and thermogenic capacity. PVN-injected CART (55-102, 100 pmol) significantly decreased NPY-induced feeding at 1, 2 and 4 h, but did not significantly affect deprivation-induced feeding. CART induced gene expression of uncoupling protein 1 (UCP1), UCP2, and UCP3 in brown and white adipose tissue and biceps femoris muscle respectively. These results indicate the PVN as a specific site of CART action, and suggest that CART in the PVN may have an important influence on energy metabolism. (C) 2000 Lippincott Williams and Wilkins.

Original language	English (US)
Pages (from-to)	3251-3255
Number of pages	5
Journal	Neuroreport
Volume	11
Issue number	14
DOIs	https://doi.org/10.1097/00001756-200009280-00040
State	Published - Oct 28 2000

Keywords

CART
Feeding behavior
PVN
Uncoupling protein

Access

10.1097/00001756-200009280-00040

OpenUrl availability

Full text

Cite this

@article{a249bb35af644cf786738049a6e71d12,

title = "Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression",

abstract = "Cocaine and amphetamine regulated transcript (CART) decreases feeding and body weight after ventricular injection. CART mRNA and peptide are found in the paraventricular nucleus of the hypothalamus (PVN). The purpose of the present study was to determine effects of PVN-injected CART on feeding and thermogenic capacity. PVN-injected CART (55-102, 100 pmol) significantly decreased NPY-induced feeding at 1, 2 and 4 h, but did not significantly affect deprivation-induced feeding. CART induced gene expression of uncoupling protein 1 (UCP1), UCP2, and UCP3 in brown and white adipose tissue and biceps femoris muscle respectively. These results indicate the PVN as a specific site of CART action, and suggest that CART in the PVN may have an important influence on energy metabolism. (C) 2000 Lippincott Williams and Wilkins.",

keywords = "CART, Feeding behavior, PVN, Uncoupling protein",

author = "C. Wang and Billington, {C. J.} and Levine, {A. S.} and Kotz, {C. M.}",

year = "2000",

month = oct,

day = "28",

doi = "10.1097/00001756-200009280-00040",

language = "English (US)",

volume = "11",

pages = "3251--3255",

journal = "Neuroreport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "14",

}

TY - JOUR

T1 - Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression

AU - Wang, C.

AU - Billington, C. J.

AU - Levine, A. S.

AU - Kotz, C. M.

PY - 2000/10/28

Y1 - 2000/10/28

N2 - Cocaine and amphetamine regulated transcript (CART) decreases feeding and body weight after ventricular injection. CART mRNA and peptide are found in the paraventricular nucleus of the hypothalamus (PVN). The purpose of the present study was to determine effects of PVN-injected CART on feeding and thermogenic capacity. PVN-injected CART (55-102, 100 pmol) significantly decreased NPY-induced feeding at 1, 2 and 4 h, but did not significantly affect deprivation-induced feeding. CART induced gene expression of uncoupling protein 1 (UCP1), UCP2, and UCP3 in brown and white adipose tissue and biceps femoris muscle respectively. These results indicate the PVN as a specific site of CART action, and suggest that CART in the PVN may have an important influence on energy metabolism. (C) 2000 Lippincott Williams and Wilkins.

AB - Cocaine and amphetamine regulated transcript (CART) decreases feeding and body weight after ventricular injection. CART mRNA and peptide are found in the paraventricular nucleus of the hypothalamus (PVN). The purpose of the present study was to determine effects of PVN-injected CART on feeding and thermogenic capacity. PVN-injected CART (55-102, 100 pmol) significantly decreased NPY-induced feeding at 1, 2 and 4 h, but did not significantly affect deprivation-induced feeding. CART induced gene expression of uncoupling protein 1 (UCP1), UCP2, and UCP3 in brown and white adipose tissue and biceps femoris muscle respectively. These results indicate the PVN as a specific site of CART action, and suggest that CART in the PVN may have an important influence on energy metabolism. (C) 2000 Lippincott Williams and Wilkins.

KW - CART

KW - Feeding behavior

KW - PVN

KW - Uncoupling protein

UR - http://www.scopus.com/inward/record.url?scp=0034727445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034727445&partnerID=8YFLogxK

U2 - 10.1097/00001756-200009280-00040

DO - 10.1097/00001756-200009280-00040

M3 - Article

C2 - 11043558

AN - SCOPUS:0034727445

SN - 0959-4965

VL - 11

SP - 3251

EP - 3255

JO - Neuroreport

JF - Neuroreport

IS - 14

ER -

Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression

Abstract

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this