Effect of chronic morphine treatment on brain chromatin template activities in mice

Nancy M. Lee; Ing K. Ho; Horace H. Loh

doi:10.1016/0006-2952(75)90386-X

Effect of chronic morphine treatment on brain chromatin template activities in mice

Nancy M. Lee, Ing K. Ho, Horace H. Loh

Pharmacology

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Abstract

Chromatins have been isolated from both placebo- and chronic morphine-treated mice. The specific activity of chromatin-directed UTP incorporation was measured. Evidence is presented to show that the chromatin template activity isolated from tolerant animals is increased. The increase may be due to the alteration of non-histone protein in chromatin. This is a narcotic-specific phenomenon, since the morphine-induced increase can be blocked by naloxone.

Original language	English (US)
Pages (from-to)	1983-1987
Number of pages	5
Journal	Biochemical Pharmacology
Volume	24
Issue number	21
DOIs	https://doi.org/10.1016/0006-2952(75)90386-X
State	Published - Nov 1 1975

Bibliographical note

Funding Information:
Acknowledgements These studies were supported in part by NIMH grants DA-00563 and DA-00564 and U.S. Army Research Contract DADA-17-73-C-3006.

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title = "Effect of chronic morphine treatment on brain chromatin template activities in mice",

abstract = "Chromatins have been isolated from both placebo- and chronic morphine-treated mice. The specific activity of chromatin-directed UTP incorporation was measured. Evidence is presented to show that the chromatin template activity isolated from tolerant animals is increased. The increase may be due to the alteration of non-histone protein in chromatin. This is a narcotic-specific phenomenon, since the morphine-induced increase can be blocked by naloxone.",

author = "Lee, {Nancy M.} and Ho, {Ing K.} and Loh, {Horace H.}",

note = "Funding Information: Acknowledgements These studies were supported in part by NIMH grants DA-00563 and DA-00564 and U.S. Army Research Contract DADA-17-73-C-3006.",

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AU - Lee, Nancy M.

AU - Ho, Ing K.

AU - Loh, Horace H.

N1 - Funding Information: Acknowledgements These studies were supported in part by NIMH grants DA-00563 and DA-00564 and U.S. Army Research Contract DADA-17-73-C-3006.

PY - 1975/11/1

Y1 - 1975/11/1

N2 - Chromatins have been isolated from both placebo- and chronic morphine-treated mice. The specific activity of chromatin-directed UTP incorporation was measured. Evidence is presented to show that the chromatin template activity isolated from tolerant animals is increased. The increase may be due to the alteration of non-histone protein in chromatin. This is a narcotic-specific phenomenon, since the morphine-induced increase can be blocked by naloxone.

AB - Chromatins have been isolated from both placebo- and chronic morphine-treated mice. The specific activity of chromatin-directed UTP incorporation was measured. Evidence is presented to show that the chromatin template activity isolated from tolerant animals is increased. The increase may be due to the alteration of non-histone protein in chromatin. This is a narcotic-specific phenomenon, since the morphine-induced increase can be blocked by naloxone.

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JO - Biochemical Pharmacology

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ER -

Effect of chronic morphine treatment on brain chromatin template activities in mice

Abstract

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