Effect of cortisone on cells at the bone-marrow interface

David J. Simmons, Louis Kidder, Mary Thomas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A study of the association between the rate of proliferation of marrow fibroblast-like stromal cells (in vitro) and the rate of endosteal bone mineralization (EsMR) (in vivo) was undertaken in an osteopenic rat model. We report than 200 g male rats treated with cortisone acetate (5 mg/day for 7 days) exhibit decreases in marrow fibroblast colony-forming units (FCFU) and tetracycline-based measurements of EsMR at the level of the femoral midshaft. In cortisone-treated rats recovering for 1-3 weeks, the FCFU census and EsMR normalized during the first posttreatment week, remained at control levels after 2-3 weeks, and exhibited a relapse in the third week which signified only partial recovery. These changes were unrelated to patterns of body weight gain. The data indicate that the FCFU census can serve to index endosteal osteoblast vigor.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalCalcified Tissue International
Volume46
Issue number5
DOIs
StatePublished - May 1 1990

Keywords

  • Bone formation
  • Glucocorticoid
  • Marrow
  • Osteopenia
  • Stromal cell

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