Effect of dexmedetomidine on pulmonary artery pressure in children with congenital heart disease and pulmonary hypertension

Muralidhar Kanchi, Devdas Thomas Inderbitzin, Kadam Naina Ramesh, Pujar Venkateshauarya Suresh, Shreesha Shankar Mayya, Shanthi Sivanandam, Kumar Belani

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study was undertaken to determine the effects of dexmedetomidine on pulmonary artery pressure (PAP) in children with congenital heart disease (CHD) and pulmonary hypertension (PH) undergoing cardiac catheterization with and without a planned intervention during monitored anesthetic care using midazolam and ketamine. Materials and Methods: Children (<18 years) with known CHD and PH who were scheduled for cardiac catheterization and interventional procedures were included in the study. The procedures were performed under monitored anesthesia. After obtaining baseline PAPs, an intravenous (IV) infusion of dexmedetomidine (1 μg/kg) was given for over 10 min. During infusion, heart rate (HR), blood pressure (BP), respiratory rate (RR), and peripheral arterial oxygen saturation (SPO2) were recorded every 2 min until completion of dexmedetomidine infusion, 15 min later, and when the procedure was completed. In addition, pulmonary artery systolic and diastolic pressures, and mean pulmonary artery pressure (MPAP) were recorded and the pulmonary artery systolic pressure (PASP)/systolic blood pressure (BP) ratio was calculated. Results: All children tolerated the procedure without adverse events. The HR decreased significantly over time during dexmedetomidine infusion. The changes in systemic systolic BP and PAPs were not significantly different from the baseline value at all points of measurement as was the ratio between the systolic pulmonary artery and systolic systemic BPs. Conclusions: Administration of dexmedetomidine in a dose of 1 μg/kg over 10 min did not significantly alter the PAP in children with CHD and PH. There was a decrease in the HR that was not clinically significant. The children tolerated dexmedetomidine without adverse events.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalAnnals of Cardiac Anaesthesia
Volume23
Issue number4
DOIs
StatePublished - Oct 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Annals of Cardiac Anaesthesia | Published by Wolters Kluwer - Medknow.

Keywords

  • congenital heart disease
  • dexmedetomidine
  • mean pulmonary artery pressure
  • pulmonary artery systolic pressure
  • pulmonary hypertension
  • α2-agonist

PubMed: MeSH publication types

  • Journal Article

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