TY - JOUR
T1 - Effect of dietary flaxseed on serum levels of estrogens and androgens in postmenopausal women
AU - Sturgeon, Susan R.
AU - Heersink, Joanna L.
AU - Volpe, Stella L.
AU - Bertone-Johnson, Elizabeth R.
AU - Puleo, Elaine
AU - Stanczyk, Frank Z.
AU - Sabelawski, Sara
AU - Wähälä, Kristina
AU - Kurzer, Mindy S.
AU - Bigelow, Carol
N1 - Funding Information:
This research was supported by a grant from the United States Department of Defense Breast Cancer Research Program (Grant DAMD17–02–1–0470–1).
PY - 2008/9
Y1 - 2008/9
N2 - Flaxseed is a rich source of dietary lignans. Experimental studies suggest lignans may exert breast cancer preventive effects through hormonal mechanisms. Our aim was to study the effects of flaxseed on serum sex hormones implicated in the development of breast cancer. Forty-eight postmenopausal women participated in a 12-wk preintervention-postintervention study. Participants consumed 7.5 g/day of ground flaxseed for the first 6 wk and 15.0 grams/day for an additional 6 wk. Nonsignificant declines were noted over the 12 wk (95% confidence intervals) for estradiol (pg/ml), estrone (pg/ml), and testosterone (pg/ml): -4.4 (-12.6 to 3.9), -3.3 (-7.7 to 1.2), -4.7 (-17.8 to 8.5), respectively. Changes tended to be more pronounced in overweight/obese women, particularly for estrone (-6.5, -11.9 to -1.2; P =.02). Our results suggest that dietary flaxseed may modestly lower serum levels of sex steroid hormones, especially in overweight/obese women.
AB - Flaxseed is a rich source of dietary lignans. Experimental studies suggest lignans may exert breast cancer preventive effects through hormonal mechanisms. Our aim was to study the effects of flaxseed on serum sex hormones implicated in the development of breast cancer. Forty-eight postmenopausal women participated in a 12-wk preintervention-postintervention study. Participants consumed 7.5 g/day of ground flaxseed for the first 6 wk and 15.0 grams/day for an additional 6 wk. Nonsignificant declines were noted over the 12 wk (95% confidence intervals) for estradiol (pg/ml), estrone (pg/ml), and testosterone (pg/ml): -4.4 (-12.6 to 3.9), -3.3 (-7.7 to 1.2), -4.7 (-17.8 to 8.5), respectively. Changes tended to be more pronounced in overweight/obese women, particularly for estrone (-6.5, -11.9 to -1.2; P =.02). Our results suggest that dietary flaxseed may modestly lower serum levels of sex steroid hormones, especially in overweight/obese women.
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U2 - 10.1080/01635580801971864
DO - 10.1080/01635580801971864
M3 - Article
C2 - 18791924
AN - SCOPUS:51849114706
SN - 0163-5581
VL - 60
SP - 612
EP - 618
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 5
ER -
