TY - JOUR
T1 - Effect of dietary vitamin E and aging on tissue lipofuscin pigment concentration in mice
AU - Csallany, A S
AU - Ayaz, K. L.
AU - Su, L. C.
PY - 1977
Y1 - 1977
N2 - This study reports a re-investigation of the effect of dietary vitamin E upon tissue organic solvent soluble lipofuscin pigment concentrations. Female weanling mice were fed a vitamin E deficient, vitamin E or N,N'-diphenyl-phenylenediamine (DPPD) supplemented diet up to 18 mth of age. Lipofuscin concentrations were measured by a quantitative method which is based on fluorescence spectroscopy. Of all tissues measured (uterus, lung, spleen, kidney, liver, heart and brain), only the liver responded and showed lower pigment concentrations due to vitamin E treatment. In addition, in the liver, up to 12 mth of age, vitamin E supplementation resulted in gradually decreasing pigment concentrations, but by 18 mth of age, pigment concentrations were increased by 5 to 10 times in all diet groups. The effect of DPPD was similar to vitamin E. Tissue lipofuscin pigment concentrations in 18-mth-old mice were lowest in the uterus and highest in the heart. The data indicate the possibility of a turnover of the organic solvent soluble lipofuscin pigments in the liver.
AB - This study reports a re-investigation of the effect of dietary vitamin E upon tissue organic solvent soluble lipofuscin pigment concentrations. Female weanling mice were fed a vitamin E deficient, vitamin E or N,N'-diphenyl-phenylenediamine (DPPD) supplemented diet up to 18 mth of age. Lipofuscin concentrations were measured by a quantitative method which is based on fluorescence spectroscopy. Of all tissues measured (uterus, lung, spleen, kidney, liver, heart and brain), only the liver responded and showed lower pigment concentrations due to vitamin E treatment. In addition, in the liver, up to 12 mth of age, vitamin E supplementation resulted in gradually decreasing pigment concentrations, but by 18 mth of age, pigment concentrations were increased by 5 to 10 times in all diet groups. The effect of DPPD was similar to vitamin E. Tissue lipofuscin pigment concentrations in 18-mth-old mice were lowest in the uterus and highest in the heart. The data indicate the possibility of a turnover of the organic solvent soluble lipofuscin pigments in the liver.
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U2 - 10.1093/jn/107.10.1792
DO - 10.1093/jn/107.10.1792
M3 - Article
C2 - 903824
AN - SCOPUS:0017666054
SN - 0022-3166
VL - 107
SP - 1792
EP - 1799
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 10
ER -