Effect of dynorphin-(1-13) and related peptides on respiratory rate and morphine-induced respiratory rate depression

S. K. Woo, F. C. Tulunay, H. H. Loh, N. M. Lee

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26 Scopus citations

Abstract

Previous studies from our laboratory have shown that the opioid peptide dynorphin-(1-13), although not analgesic when given by itself, can inhibit morphine-induced analgesia in naive mice and potentiate it in morphine tolerant mice. In the present study, we examined the effect of dynorphin-(1-13) with two other dynorphin-like peptides, α-neoendorphin and dynorphin-(1-10) amide, on respiration. Our results show that none of the peptides studied had any significant activity on the respiratory rate in mice when given alone. However, in the presence of morphine, dynorphin-(1-13) antagonized the morphine-induced respiratory rate depression in morphine-tolerant animals; α-neoendorphin enhanced the morphine-induced respiratory rate depression in naive but had no effect in morphine-tolerant animals and dynorphin-(1-10) amide had no modulatory effect on the morphine-induced respiratory rate depression in either group of animals.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalEuropean Journal of Pharmacology
Volume96
Issue number1-2
DOIs
StatePublished - Dec 9 1983

Bibliographical note

Funding Information:
Supported by NIDA Grant DA-005(>4, DA-02643 and 5-KO2-DA-00020 (NML) and 5-KO2-DA-70554 (HHL).

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Dynorphin-(1-10) amide
  • Dynorphin-(1-13)
  • Morphine
  • Morphine-tolerant mice
  • Naive mice
  • Respiratory rate
  • α-Neoendorphin

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