Effect of endosulfan during fetal gonadal differentiation on spermatogenesis in rats

Neelima Sinha, Neeta Adhikari, Daya K. Saxena

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Pregnant rats were exposed to endosulfan (1 or 2 mg/kg per day) from day 12 of gestation through parturition. Male neonates were fostered to untreated dams. At 100 days of age, the male offspring were sacrificed. Exposure to endosulfan during fetal gonadal differentiation altered the process of spermatogenesis by affecting testicular lactate dehydrogenase and sorbitol dehydrogenase. Reduction in spermatid count in testis and sperm count in cauda epididymis was observed. Testis, epididymis and seminal vesicle showed significant decrease in weights in both the treated groups while no effect on prostate weight was recorded. Hence it can be suggested that endosulfan interferes in the process of spermatogenesis. The overall toxicity was dose dependent.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalEnvironmental Toxicology and Pharmacology
Issue number1-2
StatePublished - 2001
Externally publishedYes

Bibliographical note

Funding Information:
The authors are grateful to the Director, Dr P.K. Seth, Industrial Toxicology Research Centre, Lucknow, India, for his interest in this study. Authors N. Sinha and N. Adhikari are thankful to the Council of Scientific and Industrial Research, India for providing financial assistance. We thank M/S Bharat Pulverising Mills Pvt Ltd. Mumbai for the gift of a sample of technical grade endosulfan.

Copyright 2007 Elsevier B.V., All rights reserved.


  • Endosulfan
  • Prenatal
  • Rat
  • Spermatogenesis

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