Effect of estrogens on β-hydroxy-β-methylglutaryl coenzyme a reductase activity and cholesterol levels

Yusuf J. Abul-Hajj

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The effect of estrogens on hepatic β-hydroxy-β-methylglutaryl coenzyme A reductase activity and cholesterol in serum and liver of ovarietcomized rats on normal diet, 2% cholestyramine diet or 2% cholesterol diet was investigated. Estrogen administration to ovariectomized rats on normal diet resulted in increased reductase activity and was correlated with decreased serum cholesterol and increased liver cholesterol levels wlth mestranol (ME), ethinyl estradiol (EE) and estradiol benzoate (EB, 250 μg) but increased serum and liver cholesterol levels with 25 μg and 100 μg EB administration. The increased stimulation of reductase activity by estrogen administration was absolished when rats were fed a 2% cholesterol diet. Cholestyramine feeding markedly increased reductase activity in livers of ovariectomized rats. These studies show that estrogens are not absolutely required for the stimulation of reductase activity and therefore is consistent with the model in which cholesterol functions as a feedback repressor of reductase activity.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
Issue number6
StatePublished - Jun 1981

Bibliographical note

Funding Information:
This work was supported in part by a grant from the Graduate School, University of Minnesota. The excellent technical assistance of Robert C. Allen and Dale Grothe is greatly appreciated. We also wish to thank Dr. John W. Porter for helpful discussions.


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