TY - JOUR
T1 - Effect of gene environment interactions on lung function and cardiovascular disease in COPD
AU - Hackett, Tillie Louise
AU - Stefanowicz, Dorota
AU - Aminuddin, Farzian
AU - Sin, Don D.
AU - Connett, John E.
AU - Anthonisen, Nicholas R.
AU - Paré, Peter D.
AU - Sandford, Andrew J.
PY - 2011
Y1 - 2011
N2 - Background: The objective of this study was to determine if gene-environment interactions between cigarette smoking and interleukin-6 (IL6), interferon-γ (IFNG), interleukin-1 β (IL1B), or interleukin-1 receptor antagonist (IL1RN) single nucleotide polymorphisms are associated with lung function decline and cardiovascular disease in chronic obstructive pulmonary disease (COPD). Methods: Single nucleotide polymorphisms (SNPs) in IL6, IFNG, IL1B, and IL1RN were genotyped in the Lung Health Study and correlated with rate of decline of forced expiratory volume in 1 second (FEV 1) over 5 years, baseline FEV1, serum protein levels, cardiovascular disease, and interactions with smoking. Results: The IL6 rs2069825 single nucleotide polymorphism was associated with the rate of decline of prebronchodilator FEV 1 (P = 0.049), and was found to have a significant interaction (P = 0.004) with mean number of cigarettes smoked per day. There was also a signifcant interaction of IFNG rs2069727 with smoking on prebronchodilator (P = 0.008) and postbron-chodilator (P = 0.01) FEV1 The IL6 polymorphism was also associated with cardiovascular disease in heterozygous individuals (P = 0.044), and was found to have a significant interaction with smoking (P = 0.024). None of the genetic variants were associated with their respective serum protein levels. Conclusion: The results suggest interactions of IL6 rs2069825 and IFNG rs2069727 single nucleotide polymorphisms with cigarette smoking on measures of lung function. The IL6 rs2069825 single nucleotide polymorphism also interacted with smoking to affect the risk of cardiovascular disease in COPD patients.
AB - Background: The objective of this study was to determine if gene-environment interactions between cigarette smoking and interleukin-6 (IL6), interferon-γ (IFNG), interleukin-1 β (IL1B), or interleukin-1 receptor antagonist (IL1RN) single nucleotide polymorphisms are associated with lung function decline and cardiovascular disease in chronic obstructive pulmonary disease (COPD). Methods: Single nucleotide polymorphisms (SNPs) in IL6, IFNG, IL1B, and IL1RN were genotyped in the Lung Health Study and correlated with rate of decline of forced expiratory volume in 1 second (FEV 1) over 5 years, baseline FEV1, serum protein levels, cardiovascular disease, and interactions with smoking. Results: The IL6 rs2069825 single nucleotide polymorphism was associated with the rate of decline of prebronchodilator FEV 1 (P = 0.049), and was found to have a significant interaction (P = 0.004) with mean number of cigarettes smoked per day. There was also a signifcant interaction of IFNG rs2069727 with smoking on prebronchodilator (P = 0.008) and postbron-chodilator (P = 0.01) FEV1 The IL6 polymorphism was also associated with cardiovascular disease in heterozygous individuals (P = 0.044), and was found to have a significant interaction with smoking (P = 0.024). None of the genetic variants were associated with their respective serum protein levels. Conclusion: The results suggest interactions of IL6 rs2069825 and IFNG rs2069727 single nucleotide polymorphisms with cigarette smoking on measures of lung function. The IL6 rs2069825 single nucleotide polymorphism also interacted with smoking to affect the risk of cardiovascular disease in COPD patients.
KW - Cardiovascular disease
KW - Chronic obstructive pulmonary disease
KW - Forced expiratory volume in one second
KW - Gene-environment interactions
KW - Interleukin-6
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U2 - 10.2147/COPD.S18279
DO - 10.2147/COPD.S18279
M3 - Article
C2 - 21814463
AN - SCOPUS:84856389499
SN - 1176-9106
VL - 6
SP - 277
EP - 287
JO - International Journal of COPD
JF - International Journal of COPD
IS - 1
ER -