TY - JOUR
T1 - Effect of Gross Total Resection in World Health Organization Grade II Astrocytomas
T2 - SEER-Based Survival Analysis
AU - Schupper, Alexander J.
AU - Hirshman, Brian R.
AU - Carroll, Kate T.
AU - Ali, Mir Amaan
AU - Carter, Bob S.
AU - Chen, Clark C.
PY - 2017/7
Y1 - 2017/7
N2 - Introduction We sought to compare the survival benefit associated with gross total resection (GTR) in World Health Organization grade II astrocytomas (A2) with those of grade III (A3) and grade IV (glioblastoma) astrocytomas. Methods Using the Surveillance, Epidemiology, and End Results program database (1999–2010), we identified 4113 A2 patients. Surgical resection was defined as GTR, subtotal resection (STR), or no resection. Kaplan-Meier and multivariate Cox proportional hazards analyses were used to assess survival with respect to extent of resection. Results were compared with the benefit of GTR over STR in 2755 A3 and 21,962 glioblastoma patients from the same database. Results A multivariate Cox proportional hazards analysis indicated that A2 patients who underwent a GTR had a 28.3% reduction in the hazard of death relative to A2 patients who underwent STR. Similar risk reductions were observed in A2 patients age <50 and ≥50. However, because of differences in the natural history of these cohorts, the relative hazard reduction translated into distinct overall survival profiles. For A2 patients ≥50 years old, the GTR-associated survival benefit was approximately 6 months, resembling that observed in glioblastoma patients. In contrast, GTR in A2 patients <50 years old was associated with survival profiles superior to those observed in A3 patients. Conclusions In the Surveillance, Epidemiology, and End Results (SEER) program database, GTR-associated survival benefit in A2 patients ≥50 years old resembled that observed in glioblastoma, while GTR in A2 patients <50 years old was associated with a distinctly more favorable survival profile.
AB - Introduction We sought to compare the survival benefit associated with gross total resection (GTR) in World Health Organization grade II astrocytomas (A2) with those of grade III (A3) and grade IV (glioblastoma) astrocytomas. Methods Using the Surveillance, Epidemiology, and End Results program database (1999–2010), we identified 4113 A2 patients. Surgical resection was defined as GTR, subtotal resection (STR), or no resection. Kaplan-Meier and multivariate Cox proportional hazards analyses were used to assess survival with respect to extent of resection. Results were compared with the benefit of GTR over STR in 2755 A3 and 21,962 glioblastoma patients from the same database. Results A multivariate Cox proportional hazards analysis indicated that A2 patients who underwent a GTR had a 28.3% reduction in the hazard of death relative to A2 patients who underwent STR. Similar risk reductions were observed in A2 patients age <50 and ≥50. However, because of differences in the natural history of these cohorts, the relative hazard reduction translated into distinct overall survival profiles. For A2 patients ≥50 years old, the GTR-associated survival benefit was approximately 6 months, resembling that observed in glioblastoma patients. In contrast, GTR in A2 patients <50 years old was associated with survival profiles superior to those observed in A3 patients. Conclusions In the Surveillance, Epidemiology, and End Results (SEER) program database, GTR-associated survival benefit in A2 patients ≥50 years old resembled that observed in glioblastoma, while GTR in A2 patients <50 years old was associated with a distinctly more favorable survival profile.
KW - Diffuse astrocytoma
KW - Gross total resection
KW - WHO grade II astrocytoma
UR - http://www.scopus.com/inward/record.url?scp=85019597316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019597316&partnerID=8YFLogxK
U2 - 10.1016/j.wneu.2017.03.140
DO - 10.1016/j.wneu.2017.03.140
M3 - Article
C2 - 28419878
AN - SCOPUS:85019597316
SN - 1878-8750
VL - 103
SP - 741
EP - 747
JO - World neurosurgery
JF - World neurosurgery
ER -