Effect of Johne's disease status on reproduction and culling in dairy cattle

R. L. Smith, R. L. Strawderman, Y. H. Schukken, S. J. Wells, A. K. Pradhan, L. A. Espejo, R. H. Whitlock, J. S. Van Kessel, J. M. Smith, D. R. Wolfgang, Y. T. Gröhn

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Among the costs attributed to Mycobacterium avium ssp. paratuberculosis (MAP) infection in dairy cattle, the effects on reproduction and culling are the least documented. To estimate the cost of MAP infections and Johne's disease in a dairy herd, the rates of calving and culling were calculated for cows in each stage of MAP infection relative to uninfected cows. Data from 6 commercial dairy herds, consisting of 2,818 cows with 2,754 calvings and 1,483 cullings, were used for analysis. Every cow in each study herd was tested regularly for MAP, and herds were followed for between 4 and 7 yr. An ordinal categorical variable for Johne's disease status [test-negative, low-positive (low-shedding or ELISA-positive only), or high-shedding] was defined as a time-dependent variable for all cows with at least 1 positive test result or 2 negative test results. A Cox regression model, stratified on herd and controlling for the time-dependent infection variable, was used to analyze time to culling. Nonshedding animals were significantly less likely to be culled in comparison with animals in the low-shedding or ELISA-positive category, and high-shedding animals had nonsignificantly higher culling rates than low-shedding or ELISA-positive animals. Time to calving was analyzed using a proportional rates model, an analog to the Andersen-Gill regression model suitable for recurrent event data, stratifying on herd and weighted to adjust for the dependent censoring caused by the culling effects described above. High-shedding animals had lower calving rates in comparison with low-shedding or ELISA-positive animals, which tended to have higher calving rates than test-negative animals.

Original languageEnglish (US)
Pages (from-to)3513-3524
Number of pages12
JournalJournal of Dairy Science
Volume93
Issue number8
DOIs
StatePublished - Aug 2010

Bibliographical note

Funding Information:
The USDA (Cooperative State Research, Education and Extension Service, Washington, DC) Award Number 2008-35204-04627 provided funding for this study, as did the USDA-Agricultural Research Service (Agreements 58-1265-3-155, 58-1265-3-156, 58-1265-3-158, and 58-1265-4-020) for the Regional Dairy Quality Management Alliance (RDQMA; Beltsville, MD) and the Johne's Disease Integrated Program (JDIP; University Park, PA; USDA contract 45105).

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • Culling
  • Johne's disease
  • Reproduction
  • Survival analysis

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