Abstract
The long-term effects of clofibric acid (200 mg/kg body weight) injected subcutaneously from 6-36 weeks of age were assessed in obese, hyperlipemic Zucker rats. At 18 and 36 weeks of age, treated rats had significantly lower fasted serum cholesterol levels but triacylglycerol levels were not affected. Rats were killed at 36 weeks of age at which time there were no differences in body and kidney weights between control and clofibric acid-treated rats. Liver, spleen and heart weights were lowered by clofibric acid treatment. In liver there was an elevation of lipid/g due to treatment but there were no effects on cholesterol/g or on either total liver lipid or cholesterol levels. In the epididymal fat pad of clofibric acid-treated rats, there was a 21% elevation of cholesterol level on a per pad basis. In the other organs, there were no effects of treatment on lipid or cholesterol levels except for lowered total cholesterol in kidney. Several liver lipogenic enzymes were lowered by treatment but malic enzyme was two times higher.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-112 |
| Number of pages | 6 |
| Journal | Atherosclerosis |
| Volume | 66 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jul 1987 |
| Externally published | Yes |
Bibliographical note
Funding Information:This research was supported by Grants HL 08214, AM 37396 and AM 37112 from the National Institutes of Health and by The Hormel Foundation.
Keywords
- Adipose tissue cellularity
- Fatty acid synthesis
- Glucose-6-phosphate dehydrogenase
- Malic enzyme
