Insulin secretory reserve assessed by the method of glucose potentiation of arginine-induced insulin secretion is decreased in nondiabetic transplant recipients using triple immunosuppressive therapy with prednisone, cyclosporine, and azathioprine. To determine whether this defect is due to the combined therapy or to a single agent, we examined the acute insulin response (AIR) to arginine at 5 levels of glucose (basal and 4 levels achieved by continuous glucose infusions) in 7 normoglycemic arthritis patients (AP) using long-term prednisone (10.3 ± 37mg for 83 ± 37 months), and 4 normoglycemic psoriasis patients (PP) using long-term cyclosporine (350 ± 61 mg for 25 ± 4 months) and compared them with matched healthy controls (CON). Long-term cyclosporine (ANOVA p = 0.016 compared to control subjects) but not prednisone treatment decreased insulin secretory reserve. We conclude that cyclosporine might have an adverse effect on beta-cell function and contribute to posttransplant diabetes.
|Translated title of the contribution||Effect of long-term cyclosporine and long-term prednisone therapy on insulin secretory reserve|
|Number of pages||3|
|Journal||Schweizerische Medizinische Wochenschrift|
|State||Published - Jan 1 1994|