Abstract
Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period.
Original language | English (US) |
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Pages (from-to) | 93-95 |
Number of pages | 3 |
Journal | Alcohol |
Volume | 6 |
Issue number | 2 |
DOIs | |
State | Published - 1989 |
Externally published | Yes |
Keywords
- Alcohol
- Behavioral "despair"
- Desipramine
- Imipramine
- Neonatal
- Nomifensine