In two previous studies, CBD neonatal piglets demonstrated hypoventilation during eupnea, low weight gain and highly irregular breathing. In addition, one of the studies noted a high mortality rate (J. Appl. Physiol 68(3): 1048-1052, 1990) which was not observed in the other (J. Appl. Physiol. 80(1):323-331, 1996). The purpose of our studies was to further investigate the effects of neonatal CBD. Midline incision CBD surgery was performed on piglets at less than 5 days of age or 10-15 days of age. In the first litter, 3 of 4 CBD piglets had low weight gain, highly irregular breathing and evidence of upper airway dysfunction. One CBD piglet died apparently of malnutrition. In a second litter, extreme care was taken to minimize potential surgical damage to the airway. These CBD piglets showed normal weight gain though some still demonstrated irregular breathing, evidence of upper airway dysfunction and hypoventilation during eupnea (ΔPaCO2 = 25.9 mmHg). There were no mortalities in these piglets. Based on these data, we conclude that midline incision CBD in neonatal piglets can potentially have major effects on breathing, airway function and food intake.
|Original language||English (US)|
|State||Published - Mar 20 1998|