Effect of prolonged exercise training without weight loss on high- density lipoprotein metabolism in overweight men

Paul D. Thompson; Susan M. Yurgalevitch; Mary M. Flynn; Joseph M. Zmuda; Donna Spannaus-Martin; Ann Saritelli; Linda Bausserman; Peter N. Herbert

doi:10.1016/S0026-0495(97)90305-X

Effect of prolonged exercise training without weight loss on high- density lipoprotein metabolism in overweight men

Paul D. Thompson, Susan M. Yurgalevitch, Mary M. Flynn, Joseph M. Zmuda, Donna Spannaus-Martin, Ann Saritelli, Linda Bausserman, Peter N. Herbert

Medical Laboratory Sciences

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

This study examined the effect of exercise training without weight loss on high-density lipoprotein (HDL) metabolism in overweight men. We evaluated HDL metabolism using ¹²⁵I-radiolabeled autologous HDL in 17 overweight men aged 40 ± 7 years (mean ± SD) before and after 1 year of exercise training. Subjects consumed defined diets in a metabolic kitchen during the metabolic studies. They performed endurance exercise under supervision for 1 hour four times weekly and maintained their pretraining body weight. Maximal oxygen uptake (V̇O₂max) increased 27% (P < .001) with exercise training. HDL- cholesterol (HDL-C) and apolipoprotein (apo) A-I increased 10% and 9%, respectively (P < .001 for both), whereas triglycerides and apo B decreased 7% and 10%, respectively (P < .05). Postheparin lipoprotein lipase increased 11% (P = NS). Hepatic triglyceride lipase activity (HTGLA) decreased 12% (P < .05). The fractional catabolic rate (FCR) of HDL protein and of apo A-I decreased 5% and 7%, respectively (P < .05 for both). The synthetic rate of apo A-I increased 13% (P < .01). Increased HDL after exercise training is associated with both decreased HDL protein catabolism and increased HDL apo A-I synthesis. Weight loss is not required to increase HDL-C with exercise training in overweight men, but without weight loss, even prolonged exercise training produces only modest changes in HDL-C concentrations.

Original language	English (US)
Pages (from-to)	217-223
Number of pages	7
Journal	Metabolism: clinical and experimental
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/S0026-0495(97)90305-X
State	Published - 1997

Bibliographical note

Funding Information:
From the Lipid Research Laboratory, Division of Cardiolog3; The Miriam Hospital and Brown University, Providence, RI; and the Division of Cardiology, University of Pittsburgh, Pittsburgh, PA. Submitted May 21, 1996; accepted August 6, 1996. Supported by National Institutes of Health Grant No. HL-28467 and by the Miriam Foundation, the Haire Family, William Jakober, and the McNul~ Family. Address reprint requests to Paul D. Thompson, MD, 1212 Kaufmann Building, University of Pittsburgh Heart Institute, 200 Lothrop St, Pittsburgh, PA 15213. Copyright © 1997 by W.B. Saunders Company 0026-0495/97/4602-0019503.00/0

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title = "Effect of prolonged exercise training without weight loss on high- density lipoprotein metabolism in overweight men",

abstract = "This study examined the effect of exercise training without weight loss on high-density lipoprotein (HDL) metabolism in overweight men. We evaluated HDL metabolism using 125I-radiolabeled autologous HDL in 17 overweight men aged 40 ± 7 years (mean ± SD) before and after 1 year of exercise training. Subjects consumed defined diets in a metabolic kitchen during the metabolic studies. They performed endurance exercise under supervision for 1 hour four times weekly and maintained their pretraining body weight. Maximal oxygen uptake ({\.V}O2max) increased 27% (P < .001) with exercise training. HDL- cholesterol (HDL-C) and apolipoprotein (apo) A-I increased 10% and 9%, respectively (P < .001 for both), whereas triglycerides and apo B decreased 7% and 10%, respectively (P < .05). Postheparin lipoprotein lipase increased 11% (P = NS). Hepatic triglyceride lipase activity (HTGLA) decreased 12% (P < .05). The fractional catabolic rate (FCR) of HDL protein and of apo A-I decreased 5% and 7%, respectively (P < .05 for both). The synthetic rate of apo A-I increased 13% (P < .01). Increased HDL after exercise training is associated with both decreased HDL protein catabolism and increased HDL apo A-I synthesis. Weight loss is not required to increase HDL-C with exercise training in overweight men, but without weight loss, even prolonged exercise training produces only modest changes in HDL-C concentrations.",

author = "Thompson, {Paul D.} and Yurgalevitch, {Susan M.} and Flynn, {Mary M.} and Zmuda, {Joseph M.} and Donna Spannaus-Martin and Ann Saritelli and Linda Bausserman and Herbert, {Peter N.}",

note = "Funding Information: From the Lipid Research Laboratory, Division of Cardiolog3; The Miriam Hospital and Brown University, Providence, RI; and the Division of Cardiology, University of Pittsburgh, Pittsburgh, PA. Submitted May 21, 1996; accepted August 6, 1996. Supported by National Institutes of Health Grant No. HL-28467 and by the Miriam Foundation, the Haire Family, William Jakober, and the McNul~ Family. Address reprint requests to Paul D. Thompson, MD, 1212 Kaufmann Building, University of Pittsburgh Heart Institute, 200 Lothrop St, Pittsburgh, PA 15213. Copyright {\textcopyright} 1997 by W.B. Saunders Company 0026-0495/97/4602-0019503.00/0",

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AU - Thompson, Paul D.

AU - Yurgalevitch, Susan M.

AU - Flynn, Mary M.

AU - Zmuda, Joseph M.

AU - Spannaus-Martin, Donna

AU - Saritelli, Ann

AU - Bausserman, Linda

AU - Herbert, Peter N.

N1 - Funding Information: From the Lipid Research Laboratory, Division of Cardiolog3; The Miriam Hospital and Brown University, Providence, RI; and the Division of Cardiology, University of Pittsburgh, Pittsburgh, PA. Submitted May 21, 1996; accepted August 6, 1996. Supported by National Institutes of Health Grant No. HL-28467 and by the Miriam Foundation, the Haire Family, William Jakober, and the McNul~ Family. Address reprint requests to Paul D. Thompson, MD, 1212 Kaufmann Building, University of Pittsburgh Heart Institute, 200 Lothrop St, Pittsburgh, PA 15213. Copyright © 1997 by W.B. Saunders Company 0026-0495/97/4602-0019503.00/0

PY - 1997

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N2 - This study examined the effect of exercise training without weight loss on high-density lipoprotein (HDL) metabolism in overweight men. We evaluated HDL metabolism using 125I-radiolabeled autologous HDL in 17 overweight men aged 40 ± 7 years (mean ± SD) before and after 1 year of exercise training. Subjects consumed defined diets in a metabolic kitchen during the metabolic studies. They performed endurance exercise under supervision for 1 hour four times weekly and maintained their pretraining body weight. Maximal oxygen uptake (V̇O2max) increased 27% (P < .001) with exercise training. HDL- cholesterol (HDL-C) and apolipoprotein (apo) A-I increased 10% and 9%, respectively (P < .001 for both), whereas triglycerides and apo B decreased 7% and 10%, respectively (P < .05). Postheparin lipoprotein lipase increased 11% (P = NS). Hepatic triglyceride lipase activity (HTGLA) decreased 12% (P < .05). The fractional catabolic rate (FCR) of HDL protein and of apo A-I decreased 5% and 7%, respectively (P < .05 for both). The synthetic rate of apo A-I increased 13% (P < .01). Increased HDL after exercise training is associated with both decreased HDL protein catabolism and increased HDL apo A-I synthesis. Weight loss is not required to increase HDL-C with exercise training in overweight men, but without weight loss, even prolonged exercise training produces only modest changes in HDL-C concentrations.

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Effect of prolonged exercise training without weight loss on high- density lipoprotein metabolism in overweight men

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