Effect of spontaneous and mechanical breathing on dynamic lung mechanics in hyaline membrane disease

Mark C. Mammel, Joel B. Fisher, Dennis R. Bing, Catherine W. Gatto, Stephen J. Boros

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We measured then compared the dynamic lung mechanics of spontaneous breaths and mechanical breaths in 9 mechanically ventilated neonates with hyaline membrane disease. All were receiving intermittent mandatory ventilation. All breathed spontaneously between ventilator breaths. Tidal volume, transpulmonary pressure, dynamic lung compliance, airways resistance, and peak inspiratory and peak expiratory gas flows were determined for both the mechanical and the spontaneous breaths. The mechanical breaths consistently had larger tidal volumes, higher transpulmonary pressures, higher airway resistance, and lower lung compliance values (P < 0.05). Peak inspiratory and expiratory gas flows were also higher (P < 0.01) during mechanical breathing. The spontaneous breaths generated by patients and the mechanical breaths generated by mechanical ventilators are different. The lung mechanics measurements of these two different types of breathing should be collected, analyzed, and reported separately. Pediatr Pulmonol 1990; 8:222‐225.

Original languageEnglish (US)
Pages (from-to)222-225
Number of pages4
JournalPediatric Pulmonology
Issue number4
StatePublished - 1990


  • dynamic lung compliance
  • IMV‐standard pressure preset infant ventilator
  • infants with hyaline membrane disease
  • peak flowrates
  • pulmonary resistance
  • tidal volume


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