Effect of tetrathiomolybdate administration on the excretion of copper, zinc, iron and molybdenum in sheep bile

S. R. Gooneratne; R. K. Chaplin; A. M. Trent; D. A. Christensen

doi:10.1016/0007-1935(89)90011-0

Effect of tetrathiomolybdate administration on the excretion of copper, zinc, iron and molybdenum in sheep bile

S. R. Gooneratne, R. K. Chaplin, A. M. Trent, D. A. Christensen

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Abstract

The copper (Cu), zinc (Zn), and iron (Fe) excreted daily in the bile of three sheep were estimated at 0·20, 0·10 and 0·36 mg respectively. Intravenous administration of tetrathiomolybdate (TM) increased bile Cu excretion and reduced liver Cu concentration. Tetrathiomolybdate had no significant effect on the excretion of Zn and Fe. These findings indicate that at least one of the mechanisms by which TM induces hypocuprosis is by increasing biliary Cu excretion. Hence it has a possible use in the treatment of Cu storage diseases in man and animals.

Original language	English (US)
Pages (from-to)	62-72
Number of pages	11
Journal	British Veterinary Journal
Volume	145
Issue number	1
DOIs	https://doi.org/10.1016/0007-1935(89)90011-0
State	Published - 1989
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by funds from the Natural Sciences and Engineering Research Council of Canada and Saskatchewan government sponsored Farmlab programme .

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title = "Effect of tetrathiomolybdate administration on the excretion of copper, zinc, iron and molybdenum in sheep bile",

abstract = "The copper (Cu), zinc (Zn), and iron (Fe) excreted daily in the bile of three sheep were estimated at 0·20, 0·10 and 0·36 mg respectively. Intravenous administration of tetrathiomolybdate (TM) increased bile Cu excretion and reduced liver Cu concentration. Tetrathiomolybdate had no significant effect on the excretion of Zn and Fe. These findings indicate that at least one of the mechanisms by which TM induces hypocuprosis is by increasing biliary Cu excretion. Hence it has a possible use in the treatment of Cu storage diseases in man and animals.",

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AU - Gooneratne, S. R.

AU - Chaplin, R. K.

AU - Trent, A. M.

AU - Christensen, D. A.

N1 - Funding Information: This work was supported by funds from the Natural Sciences and Engineering Research Council of Canada and Saskatchewan government sponsored Farmlab programme .

PY - 1989

Y1 - 1989

N2 - The copper (Cu), zinc (Zn), and iron (Fe) excreted daily in the bile of three sheep were estimated at 0·20, 0·10 and 0·36 mg respectively. Intravenous administration of tetrathiomolybdate (TM) increased bile Cu excretion and reduced liver Cu concentration. Tetrathiomolybdate had no significant effect on the excretion of Zn and Fe. These findings indicate that at least one of the mechanisms by which TM induces hypocuprosis is by increasing biliary Cu excretion. Hence it has a possible use in the treatment of Cu storage diseases in man and animals.

AB - The copper (Cu), zinc (Zn), and iron (Fe) excreted daily in the bile of three sheep were estimated at 0·20, 0·10 and 0·36 mg respectively. Intravenous administration of tetrathiomolybdate (TM) increased bile Cu excretion and reduced liver Cu concentration. Tetrathiomolybdate had no significant effect on the excretion of Zn and Fe. These findings indicate that at least one of the mechanisms by which TM induces hypocuprosis is by increasing biliary Cu excretion. Hence it has a possible use in the treatment of Cu storage diseases in man and animals.

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Effect of tetrathiomolybdate administration on the excretion of copper, zinc, iron and molybdenum in sheep bile

Abstract

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