In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD 50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.
Bibliographical noteFunding Information:
The authors are grateful to NMPB (National Medicinal Plants Board), New Delhi, ICMR and CSIR for providing the financial assistance.
- Antidiabetic effect
- Trichosanthes dioica