Porcine reproductive and respiratory syndrome virus (PRRSV) continues to afflict swine nearly 30 years after it was first discovered as the causative agent of “mystery swine disease”. Immunological tools of vaccination and exposure to virulent viruses have not succeeded in achieving control and prevention of PRRSV. Humoral immunity, mediated by antibodies, is a hallmark of anti-viral immunity, but little is known about the effector mechanisms of humoral immunity against PRRSV. It is essential to understand the immunological significance of antibody functions, including recently described broadly neutralizing antibodies and potential non-neutralizing activities, in the immune response to PRRSV. Here, we review recent research from PRRSV and other host-pathogen interactions to inform novel routes of exploration into PRRSV humoral immunity which may be important for identifying the immunological correlates of protection against PRRSV infection.
Bibliographical noteFunding Information:
This work was supported by Agriculture and Food Research Initiative Competitive Grant no. 2016-67015-24928 from the USDA National Institute of Food and Agriculture, and NIH award T32 OD010993 for support of MCR.
© 2017 Elsevier B.V.
- Antibody function
- B cell
- Humoral immunity
- Neutralizing antibody