Effects of a single injection of methylprednisolone acetate on serum biochemical parameters in 11 cats

Leslie C. Sharkey, Trasida Ployngam, Anthony H. Tobias, Sheila M.F. Torres

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Therapeutic use of corticosteroids has been implicated in a variety of serum biochemical abnormalities in dogs; however, the effects in cats are less well characterized. Objective: The objective of this brief communication is to report serum biochemical changes in response to methylprednisolone acetate (MPA) in adult cats. Methods: Serum biochemical profiles were performed on 11 cats with dermatologic diseases at baseline, 3-6 days, and 16-24 days after a single intramuscular dose of 5 mg/ kg MPA. Results: Median serum albumin and bicarbonate concentrations and amylase activity were increased compared to baseline at both post-treatment time points; aspartate aminotransferase activity and magnesium concentration were increased at 3-6 days post-treatment only; and alkaline phosphatase activity and total calcium concentration were increased at 16-24 days post-treatment only. Median serum creatinine concentration was decreased compared to baseline at both post-treatment time points. Examination of data from individual cats revealed significant variability in serum biochemical changes in response to MPA. No adverse clinical reactions to the drug were reported. Conclusions: A single dose of MPA results in significant changes in some serum biochemical values in cats, although individual responses will vary.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalVeterinary Clinical Pathology
Volume36
Issue number2
DOIs
StatePublished - Jun 1 2007

Keywords

  • Cat
  • Feline
  • Methylprednisolone
  • Serum biochemistry

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