Effects of alcohol use initiation on brain structure in typically developing adolescents

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Abstract

Background: Alcohol use in excessive quantities has deleterious effects on brain structure and behavior in adults and during periods of rapid neurodevelopment, such as prenatally. Whether similar outcomes characterize other developmental periods, such as adolescence, and in the context of less extensive use is unknown. Recent cross-sectional studies suggest that binge drinking as well as alcohol use disorders in adolescence are associated with disruptions in white matter microstructure and gray matter volumes. Objectives: The current study followed typically developing adolescents from a baseline assessment, where no experience with alcohol was present, through two years, after which some individuals transitioned into regular use. Methods: Participants (n=55) completed MRI scans and behavioral assessments. Results: Alcohol initiators (n=30; mean baseline age 16.7±1.3 years), compared to non-users (n=25; mean baseline age 17.1±1.2 years), showed altered patterns of neurodevelopment. They showed greater-than-expected decreases in cortical thickness in the right middle frontal gyrus from baseline to follow-up as well as blunted development of white matter in the right hemisphere precentral gyrus, lingual gyrus, middle temporal gyrus and anterior cingulate. Diffusion tensor imaging revealed a relative decrease over time in fractional anisotropy in the left caudate/thalamic region as well as in the right inferior frontal occipital fasciculus. Alcohol initiators did not differ from non-users at the baseline assessment; the groups were largely similar in other premorbid characteristics. Conclusions: Subclinical alcohol use during mid-to-late adolescence is associated with deviations in neurodevelopment across several brain tissue classes. Implications for continued development and behavior are discussed.

Original languageEnglish (US)
Pages (from-to)345-355
Number of pages11
JournalAmerican Journal of Drug and Alcohol Abuse
Volume39
Issue number6
DOIs
StatePublished - Nov 2013

Bibliographical note

Funding Information:
This work was supported by grants DA017843 and AA020033 awarded to Monica Luciana by the National Institutes of Health. The present study was also supported by BTRC grants awarded to the Center for Magnetic Resonance Research, P41 RR008079, P41 EB015894, and 1P30 NS076408 as well as by the Minnesota Supercomputing Institute. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Keywords

  • Adolescence
  • Brain development
  • MRI

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