Effects of chemical pretreatment on posttraumatic cortical edema in the rat

Michelle H. Biros, Robert Nordness

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The purpose of this study was to evaluate the effects of mannitol (Man), dexamethasone (DM), dichloroacetic acid (DCA) and 1,3-butanediol (BD) in reduction of posttraumatic cortical edema following brain deformation injury to rats. Ten minutes prior to fluid percussion injury, each animal received one of four pretreatments or placebo: Man, 1 g/kg intravenously, DM 3.0 mg/kg intravenously, DCA 25 mg/kg intraperitoneally BD 0.5 mg/kg intraperitoneally (n = 12 per treatment group), or equivolume saline (n = 8 per corresponding trauma group). Six hours after trauma, cortical tissue was harvested. Using a benzene-kerosene gradient column calibrated with potassium sulfate standards, the specific gravity (SpG) of cortical tissue from each group was measured and compared (ANOVA, P < .05). The measured cortical SpG from traumatized animals receiving Man (mean 1.037 ± SEM .001), DCA (1.038 ± .001), and BD (1.039 ± .001) were equal to SpG from traumatized cortex (1.041 ± .001), and were significantly greater than SpG from traumatized cortex for animals receiving DM (1,035 ± .001) or placebo (1.033 ± 002). Pretreatment with DCA, Man, and BD appears to protect against development of posttraumatic cortical edema when measured 6 hours after blunt head trauma in the rat. Each of these chemical treatments appears effective in preventing or reducing posttraumatic cortical edema.)

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalAmerican Journal of Emergency Medicine
Issue number1
StatePublished - 1996


  • 1,3-butanediol
  • Cerebral edema
  • cortical edema
  • dichloroacetic acid
  • fluid percussion injury
  • head trauma


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