TY - JOUR
T1 - Effects of combined behavioral intervention and tolterodine on patient-reported outcomes
AU - Wyman, Jean F.
AU - Klutke, Carl
AU - Burgio, Kathryn
AU - Guan, Zhonghong
AU - Sun, Franklin
AU - Berriman, Sandra
AU - Bavendam, Tamara
PY - 2010/8
Y1 - 2010/8
N2 - Objective: To assess the effects of tolterodine extended release (ER) plus behavioral intervention on urgency and other patient-reported outcomes in subjects with overactive bladder (OAB) who were previously dissatisfied with antimuscarinic treatment. Methods: In this 16-week, multicenter, open-label study, eligible adults (aged ≥ 18 y) reported dissatisfaction with their most recent antimuscarinic OAB medication; ≥ 8 micturitions and ≥ 2 urgency episodes per 24 hours and ≥ 1 UUI episode in 5 day bladder diaries; and OAB symptoms for ≥ 3 months. Subjects received tolterodine ER plus a behavioral educational handout with verbal reinforcement of behavioral intervention content for 8 weeks. Those satisfied with treatment at week 8 continued with this therapy; those dissatisfied received tolterodine ER plus individualized behavioral intervention (pelvic floor muscle training, tailored behavioral techniques) for 8 weeks. Endpoints were changes from baseline in daytime and nocturnal micturition-related urgency episodes and frequency-urgency sum (a measure of urgency severity and frequency) reported in 5 day bladder diaries at weeks 4, 8, 12, and 16; Patient Perception of Bladder Condition (PPBC), Overactive Bladder Questionnaire (OAB-q), and Urgency Perception Scale (UPS) scores at weeks 8 and 16. Results: Daytime and nocturnal urgency episodes and frequency-urgency sum were significantly reduced at all time points (all p < 0.0001). Significant improvements were also observed in PPBC, OAB-q Symptom Bother and Health-Related Quality of Life, and UPS scores at weeks 8 and 16 (all p < 0.0001). Conclusions: Patients with OAB who are dissatisfied with antimuscarinic therapy may experience improved treatment outcomes by adding a self-administered behavioral intervention to their drug regimen.
AB - Objective: To assess the effects of tolterodine extended release (ER) plus behavioral intervention on urgency and other patient-reported outcomes in subjects with overactive bladder (OAB) who were previously dissatisfied with antimuscarinic treatment. Methods: In this 16-week, multicenter, open-label study, eligible adults (aged ≥ 18 y) reported dissatisfaction with their most recent antimuscarinic OAB medication; ≥ 8 micturitions and ≥ 2 urgency episodes per 24 hours and ≥ 1 UUI episode in 5 day bladder diaries; and OAB symptoms for ≥ 3 months. Subjects received tolterodine ER plus a behavioral educational handout with verbal reinforcement of behavioral intervention content for 8 weeks. Those satisfied with treatment at week 8 continued with this therapy; those dissatisfied received tolterodine ER plus individualized behavioral intervention (pelvic floor muscle training, tailored behavioral techniques) for 8 weeks. Endpoints were changes from baseline in daytime and nocturnal micturition-related urgency episodes and frequency-urgency sum (a measure of urgency severity and frequency) reported in 5 day bladder diaries at weeks 4, 8, 12, and 16; Patient Perception of Bladder Condition (PPBC), Overactive Bladder Questionnaire (OAB-q), and Urgency Perception Scale (UPS) scores at weeks 8 and 16. Results: Daytime and nocturnal urgency episodes and frequency-urgency sum were significantly reduced at all time points (all p < 0.0001). Significant improvements were also observed in PPBC, OAB-q Symptom Bother and Health-Related Quality of Life, and UPS scores at weeks 8 and 16 (all p < 0.0001). Conclusions: Patients with OAB who are dissatisfied with antimuscarinic therapy may experience improved treatment outcomes by adding a self-administered behavioral intervention to their drug regimen.
KW - Antimuscarinic
KW - Behavioral intervention
KW - Combination therapy
KW - Overactive bladder
KW - Patient-reported outcomes
KW - Urgency urinary incontinence
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M3 - Article
C2 - 20735908
AN - SCOPUS:79952052663
SN - 1195-9479
VL - 17
SP - 5283
EP - 5290
JO - Canadian Journal of Urology
JF - Canadian Journal of Urology
IS - 4
ER -