Effects of corticosteroids on responses of bovine peripheral blood lymphocytes cultured with phytohemagglutinin.

C. C. Muscoplat; R. E. Shope; A. W. Chen; D. W. Johnson

Effects of corticosteroids on responses of bovine peripheral blood lymphocytes cultured with phytohemagglutinin.

C. C. Muscoplat, R. E. Shope, A. W. Chen, D. W. Johnson

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Abstract

Corticosteroids given in vivo altered the response of lymphocytes in the peripheral blood of calves. Lymphocytes were cultured and stimulated in vitro with phytohemagglutinin (PHA). After an initial suppression of lymphocyte responses to PHA, there was a rapid return to normal. It is concluded that, in calves, short-term, high-dose immunosuppressive therapy with corticosteroids produces a population of lymphocytes resistant to corticosteroids, possibly by destruction of corticosteroid-sensitive lymphocytes.

Original language	English (US)
Pages (from-to)	1243-1244
Number of pages	2
Journal	American journal of veterinary research
Volume	36
Issue number	8
State	Published - Aug 1975

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abstract = "Corticosteroids given in vivo altered the response of lymphocytes in the peripheral blood of calves. Lymphocytes were cultured and stimulated in vitro with phytohemagglutinin (PHA). After an initial suppression of lymphocyte responses to PHA, there was a rapid return to normal. It is concluded that, in calves, short-term, high-dose immunosuppressive therapy with corticosteroids produces a population of lymphocytes resistant to corticosteroids, possibly by destruction of corticosteroid-sensitive lymphocytes.",

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AB - Corticosteroids given in vivo altered the response of lymphocytes in the peripheral blood of calves. Lymphocytes were cultured and stimulated in vitro with phytohemagglutinin (PHA). After an initial suppression of lymphocyte responses to PHA, there was a rapid return to normal. It is concluded that, in calves, short-term, high-dose immunosuppressive therapy with corticosteroids produces a population of lymphocytes resistant to corticosteroids, possibly by destruction of corticosteroid-sensitive lymphocytes.

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Effects of corticosteroids on responses of bovine peripheral blood lymphocytes cultured with phytohemagglutinin.

Abstract

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